1-Boc-3-羟甲基吡咯烷合成路线 （共 21 条）
反应条件
sodium tetrahydroborate in tetrahydrofuran; methanol T=0°C; 42.5 h;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2005/49605 A1, 2005 ;
Location in patent: Page/Page column 117; 118; 158; 159 ;
反应条件
in dichloromethane T=20°C; 1 h;
参考文献
Bioorganic and medicinal chemistry letters, , vol. 12, # 13 p. 1785 - 1789
反应条件
dimethylsulfide borane complex in tetrahydrofuran T=20°C; Inert atmosphere;
参考文献
WO2012/76063 A1, ;
Page/Page column 54 ;
WO 2012/076063 A1
反应条件
methanol; sodium tetrahydroborate in tetrahydrofuran T=0°C;
参考文献
MANNKIND CORPORATION; TOLERO PHARMACEUTICALS, INC.; ZENG, Qingping; FARIS, Mary; MOLLARD, Alexis; WARNER, Steven L.; FLYNN, Gary A.
Patent: WO2014/52365 A1, 2014 ;
Location in patent: Page/Page column 239-241 ;
反应条件
sodium tetrahydroborate in tetrahydrofuran; methanol 1 h; Heating;
参考文献
Falgueyret; Oballa; Okamoto; Wesolowski; Aubin; Rydzewski; Prasit; Riendeau; Rodan; Percival
Journal of Medicinal Chemistry, 2001 , vol. 44, # 1 p. 94 - 104
反应条件
[Ru(η4-COD)(η3-methylallyl)2]; 2-(dicyclohexylphosphino)-1-(2-methoxyphenyl)-1H-imidazole; hydrogen in toluene T=160°C; P=37503.8 Torr; 24 h; AutoclaveInert atmosphere; Overall yield = 43 percentChromat.; regioselective reaction;
参考文献
Wu, Lipeng; Fleischer, Ivana; Jackstell, Ralf; Profir, Irina; Franke, Robert; Beller, Matthias
Journal of the American Chemical Society, 2013 , vol. 135, # 38 p. 14306 - 14312
反应条件
1: ammonium formate / Pd/C / methanol / 0.25 h / Heating 2: 3.82 g / K2CO3 / tetrahydrofuran; H2O / 0 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 5 p. 1151 - 1175
反应条件
1: Red-Al / toluene; tetrahydrofuran / 2.5 h / Heating 2: ammonium formate / Pd/C / methanol / 0.25 h / Heating 3: 3.82 g / K2CO3 / tetrahydrofuran; H2O / 0 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 5 p. 1151 - 1175
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-78°C; 0.166667 h; 2: tert-butyl 3-(hydroxymethyl)-1-pyrrolidinecarboxylate in dichloromethane T=-78°C; 0.75 h; 3: With triethylamine in dichloromethane T=-78 - 20°C; 2 h;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2005/49605 A1, 2005 ;
Location in patent: Page/Page column 117; 118; 159 ;
反应条件
1H-imidazole; iodine; triphenylphosphine in dichloromethane
参考文献
Bisacchi, Gregory S.; Sutton, James C.; Slusarchyk, William A.; Treuner, Uwe; Zhao, Guohua
Patent: US2004/147502 A1, 2004 ;
Location in patent: Page/Page column 36-37 ;
