1-Boc-3-羟甲基吡咯烷合成路线

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24424-99-5二碳酸二叔丁酯+

121-44-8三乙胺+

498-95-33-哌啶甲酸+

114214-69-61-Boc-3-羟甲基吡咯烷

71381-75-41-BOC-哌啶-3-羧酸

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24424-99-5二碳酸二叔丁酯+

121-44-8三乙胺+

498-95-33-哌啶甲酸+

114214-69-61-Boc-3-羟甲基吡咯烷

71381-75-41-BOC-哌啶-3-羧酸

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Bayer Aktiengesellschaft
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114214-69-61-Boc-3-羟甲基吡咯烷

138108-72-2(R)-1-Boc-3-羟甲基吡咯烷+

199174-24-8(S)-1-Boc-3-羟甲基吡咯烷

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124-63-0甲烷磺酰氯+

114214-69-61-Boc-3-羟甲基吡咯烷

141699-56-11-(叔丁氧基羰基)-3-吡咯烷甲基-甲磺酸酯

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MERCK SERONO S.A.; SWINNEN, Dominique; JORAND-LEBRUN, Catherine; GRIPPI-VALLOTTON, Tania; GERBER, Patrick; GONZALEZ, Jerome; SHAW, Jeffrey; JEYAPRAKASHNARAYANAN, Seenisamy
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421-83-0三氟甲烷磺酰氯+

114214-69-61-Boc-3-羟甲基吡咯烷

305329-96-8

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114214-69-61-Boc-3-羟甲基吡咯烷

270912-72-6

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MANNKIND CORPORATION; TOLERO PHARMACEUTICALS, INC.; ZENG, Qingping; FARIS, Mary; MOLLARD, Alexis; WARNER, Steven L.; FLYNN, Gary A.
Patent: WO2014/52365 A1, 2014 ;

114214-69-61-Boc-3-羟甲基吡咯烷

138108-72-2(R)-1-Boc-3-羟甲基吡咯烷+

199174-24-8(S)-1-Boc-3-羟甲基吡咯烷

参考文献

WO2004/108677 A1, ;

Page 138 ;
WO 2004/108677 A1

24424-99-5二碳酸二叔丁酯+

121-44-8三乙胺+

498-95-33-哌啶甲酸+

114214-69-61-Boc-3-羟甲基吡咯烷

71381-75-41-BOC-哌啶-3-羧酸

参考文献

Bayer Aktiengesellschaft
Patent: US6562811 B1, 2003 ;