2,5-二溴-3-甲氧基吡啶合成路线 （共 6 条）
反应条件
hydrogen bromide; bromine; sodium nitrite in water T=0°C; 1.66667 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; ARONOV, Alex; COME, Jon; COTTRELL, Kevin; GREY, Ronald; LE TIRAN, Amaud; MARONE, Valerie; MARTINEZ-BOTELLA, Gabriel; MESSERSMITH, David; HUCK, Emilie, Porter
Patent: WO2010/135014 A1, 2010 ;
Location in patent: Page/Page column 53-55 ;
WO 2010/135014 A1
反应条件
1.1: ethanol; water; calcium chloride; iron / 12.5 h / 75 °C 2.1: bromine / acetic acid / 16.5 h / 20 °C 2.2: 0 °C / pH 7 3.1: bromine; sodium nitrite; hydrogen bromide / water / 1.33 h / 0 °C 3.2: 1 h / 20 °C / pH 13 View Scheme
反应条件
1.1: bromine / acetic acid / 16.5 h / 20 °C 1.2: 0 °C / pH 7 2.1: bromine; sodium nitrite; hydrogen bromide / water / 1.33 h / 0 °C 2.2: 1 h / 20 °C / pH 13 View Scheme
反应条件
in methanol T=75°C; 3 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: US2011/81316 A1, 2011 ;
Location in patent: Page/Page column 14; 15 ;
反应条件
1: With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; toluene Cooling with iceReflux; 2: With hydrogenchloride in tetrahydrofuran; diethyl ether; water; toluene
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; ARONOV, Alex; COME, Jon; COTTRELL, Kevin; GREY, Ronald; LE TIRAN, Amaud; MARONE, Valerie; MARTINEZ-BOTELLA, Gabriel; MESSERSMITH, David; HUCK, Emilie, Porter
Patent: WO2010/135014 A1, 2010 ;
Location in patent: Page/Page column 53-55 ;
WO 2010/135014 A1
反应条件
1: methanol / 3 h / 75 °C 2: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 9 h / 20 - 40 °C / Inert atmosphere View Scheme
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: US2011/81316 A1, 2011 ;
