(1-(羟基甲基)环丁基)氨基甲酸叔丁酯合成路线 （共 3 条）
反应条件
1: With borane-THF in tetrahydrofuran T=-10°C; 2: With water; acetic acid in tetrahydrofuran
参考文献
ACHAOGEN, INC.; BRUSS, Jon, B.; MILLER, George, H.; AGGEN, James, Bradley; ARMSTRONG, Eliana, Saxon
Patent: WO2010/132777 A2, 2010 ;
Location in patent: Page/Page column 195; 48-49 ;
反应条件
1.1: hydrogenchloride / water / 2 h / Reflux 1.3: pH 3 2.1: borane-THF / tetrahydrofuran / -10 - 20 °C View Scheme
参考文献
ACHAOGEN, INC.; MAIANTI, Juan Pablo; AGGEN, James Bradley; DOZZO, Paola; GOLDBLUM, Adam Aaron; HILDEBRANDT, Darin James; KANE, Timothy Robert; GLIEDT, Micah James; LINSELL, Martin Sheringham; HANESSIAN, Stephen; GIGUERE, Alexandre
Patent: WO2011/44498 A1, 2011 ;
反应条件
1: With potassium bromide; 2,2,6,6-tetramethyl-piperidine-N-oxyl in dichloromethane T=-10°C; 2: With sodium hypochlorite in dichloromethane T=0°C; 0.583333 h;
参考文献
ACHAOGEN, INC.; BRUSS, Jon, B.; MILLER, George, H.; AGGEN, James, Bradley; ARMSTRONG, Eliana, Saxon
Patent: WO2010/132777 A2, 2010 ;
Location in patent: Page/Page column 196; 48 ;
