2,2-二氟-2-脱氧尿苷合成路线 （共 6 条）
反应条件
ammonia in methanol T=20°C; 15 h;
参考文献
ALIOS BIOPHARMA, INC.; Beigelman, Leonid; Wang, Guangyi; Smith, David Bernard; Deval, Jerome; Prhavc, Marija
Patent: US2013/165400 A1, 2013 ;
Location in patent: Paragraph 0420; 0421 ;
反应条件
ammonia in methanol T=23°C; 23 h;
参考文献
Chou; Heath; Patterson; Poteet; Lakin; Hunt
Synthesis, 1992 , # 6 p. 565 - 570
反应条件
1: pyridine / 15 h / 25 °C 2: acetic acid / water / 14 h / |Reflux 3: ammonia / methanol / 15 h / 20 °C View Scheme
反应条件
1: acetic acid / water / 14 h / |Reflux 2: ammonia / methanol / 15 h / 20 °C View Scheme
反应条件
water; acetic acid 24 h; Heating;
参考文献
Journal of Organic Chemistry, , vol. 53, # 11 p. 2406 - 2409
反应条件
sodium hydroxide T=40°C; 672 h; further reagent, temperature, time; Mechanism;
参考文献
Journal of Pharmaceutical Sciences, , vol. 83, # 5 p. 716 - 719
