1: tert-butyl [(1Z)-[(tert-butoxycarbonyl)amino]{[4-(4-methylpiperazin-1-yl)phenyl]amino}methylidene]carbamate With trifluoroacetic acid in dichloromethane T=20°C; 17 h; 2: 2-cyano-4,4-diethoxy-butyric acid ethyl ester With sodium methylate in methanol; ethanol T=160°C; 0.5 h; Microwave irradiation; 3: With hydrogenchloride; ammonium hydroxide more than 3 stages;

1: With trichlorophosphate T=120°C; 0.333333 h; 2: With sodium hydroxide in water T=0°C; pH=9 - 10;