5-甲基-3-苯基异恶唑-4-羧酸乙酯合成路线 （共 14 条）
反应条件
sodium hydroxide in methanol
参考文献
Xin, Zhili; Zhao, Hongyu; Serby, Michael D.; Liu, Bo; Schaefer, Verlyn G.; Falls, Douglas H.; Kaszubska, Wiweka; Colins, Christine A.; Sham, Hing L.; Liu, Gang
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 1201 - 1204
反应条件
1: water; sodium hydroxide / methanol / 4 h / 60 °C 2: borane-THF / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Kalin, Jay H.; Zhang, Hankun; Gaudrel-Grosay, Sophie; Vistoli, Giulio; Kozikowski, Alan P.
ChemMedChem, 2012 , vol. 7, # 3 p. 425 - 439
反应条件
sulfuric acid; nitric acid
T=20 - 60°C; 2.5 h;
参考文献
Caradonna,C.; Stein,M.L.
Farmaco, Edizione Scientifica, 1960 , vol. 15, p. 647 - 654
反应条件
1: HNO3, H2SO4 / 2.5 h / 20 - 60 °C
2: aq. alcali / ethanol / 12 h / Ambient temperature
View Scheme
参考文献
Caradonna,C.; Stein,M.L.
Farmaco, Edizione Scientifica, 1960 , vol. 15, p. 647 - 654
