2-[(3-氟苯氧基)甲基]苯甲酸合成路线 （共 7 条）
反应条件
1: 3-fluoro-phenol With sodium hydride in N,N-dimethyl-formamide 2: 3-oxo-1,3-dihydro-isobenzofuran in N,N-dimethyl-formamide T=160°C; 5 h;
参考文献
Laufer, Stefan A.; Ahrens, Gabriele M.; Karcher, Solveigh C.; Hering, Joerg S.; Niess, Raimund
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7912 - 7915
反应条件
hydrogenchloride in ethanol; water
参考文献
Dainippon Pharmaceutical Co., Ltd.
Patent: US4889858 A1, 1989 ;
参考文献
Kurokawa; Sato; Masuda; Yoshida; Ochi; Zushi; Fujiwara; Naruto; Uno; Matsumoto
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 10 p. 2564 - 2573
反应条件
1: 3-fluoro-phenol With sodium hydride in N,N-dimethyl-formamide 2: 3-oxo-1,3-dihydro-isobenzofuran in N,N-dimethyl-formamide T=160°C; 5 h; Product distribution / selectivity;
参考文献
MERCKLE GMBH
Patent: WO2006/120010 A2, 2006 ;
Location in patent: Page/Page column 23; 35-36 ;
反应条件
1: 92 percent / (CF3CO)2O, BF3*Et2O / CH2Cl2 / 1 h / Ambient temperature 2: 97 percent / NaBH4 / methanol / 0.33 h / 0 °C 3: SOCl2 / 0.17 h / Ambient temperature 4: CH2Cl2 / 2 h / Ambient temperature 5: 48 percent / toluene / 8 h / Heating View Scheme
参考文献
Kurokawa; Sato; Masuda; Yoshida; Ochi; Zushi; Fujiwara; Naruto; Uno; Matsumoto
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 10 p. 2564 - 2573
反应条件
boron trifluoride diethyl etherate; trifluoroacetic anhydride in dichloromethane 1 h; Ambient temperature;
参考文献
Kurokawa; Sato; Masuda; Yoshida; Ochi; Zushi; Fujiwara; Naruto; Uno; Matsumoto
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 10 p. 2564 - 2573
反应条件
1: 92 percent / (CF3CO)2O, BF3*Et2O / CH2Cl2 / 1 h / Ambient temperature 2: 97 percent / NaBH4 / methanol / 0.33 h / 0 °C 3: SOCl2 / 0.17 h / Ambient temperature 4: CH2Cl2 / 2 h / Ambient temperature 5: 48 percent / toluene / 8 h / Heating View Scheme
参考文献
Kurokawa; Sato; Masuda; Yoshida; Ochi; Zushi; Fujiwara; Naruto; Uno; Matsumoto
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 10 p. 2564 - 2573
