3-氟二苯并[b,e]氧杂卓-11(6H)-酮合成路线 （共 6 条）
反应条件
boron trifluoride diethyl etherate; trifluoroacetic anhydride in dichloromethane 1 h; Ambient temperature;
参考文献
Kurokawa; Sato; Masuda; Yoshida; Ochi; Zushi; Fujiwara; Naruto; Uno; Matsumoto
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 10 p. 2564 - 2573
反应条件
1.1: NaH / dimethylformamide 1.2: 48.5 percent / dimethylformamide / 5 h / 160 °C 2.1: 53.2 percent / PPA / tetrahydrothiophene 1,1-dioxide / 2.5 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 26 p. 7912 - 7915
反应条件
1.1: NaH / dimethylformamide 1.2: 48.5 percent / dimethylformamide / 5 h / 160 °C 2.1: 53.2 percent / PPA / tetrahydrothiophene 1,1-dioxide / 2.5 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 26 p. 7912 - 7915
反应条件
1: 74 percent / 1 h / 200 °C 2: 92 percent / (CF3CO)2O, BF3*Et2O / CH2Cl2 / 1 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 39, # 10 p. 2564 - 2573
反应条件
1: 97 percent / NaBH4 / methanol / 0.33 h / 0 °C 2: SOCl2 / 0.17 h / Ambient temperature 3: CH2Cl2 / 2 h / Ambient temperature 4: 48 percent / toluene / 8 h / Heating View Scheme
参考文献
Kurokawa; Sato; Masuda; Yoshida; Ochi; Zushi; Fujiwara; Naruto; Uno; Matsumoto
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 10 p. 2564 - 2573
反应条件
1: 97 percent / NaBH4 / methanol / 0.33 h / 0 °C 2: SOCl2 / 0.17 h / Ambient temperature 3: CH2Cl2 / 2 h / Ambient temperature 4: 48 percent / toluene / 8 h / Heating View Scheme
参考文献
Kurokawa; Sato; Masuda; Yoshida; Ochi; Zushi; Fujiwara; Naruto; Uno; Matsumoto
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 10 p. 2564 - 2573
