4-[2-(5-乙基-2-吡啶基)乙氧基]苯甲醛合成路线 （共 16 条）
反应条件
1: 2-(5-ethyl-pyridin-2-yl)ethanol With methanesulfonyl chloride; triethylamine in toluene T=20°C; 2 h; 2: 4-hydroxy-benzaldehyde With PEG 200; potassium carbonate in toluene T=80°C; 4 h;
参考文献
WO2005/49610 A1, ;
Page/Page column 16 ;
反应条件
sodium hydroxide in isopropyl alcohol 6 h; Heating;
参考文献
Gaonkar; Rai; Prabhuswamy
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 7 p. 841 - 846
反应条件
sodium hydroxide in dichloromethane; water
反应条件
in ethanol; water; ethyl acetate
反应条件
formic acid; nickel Heating;
参考文献
Momose; Meguro; Ikeda; Hatanaka; Oi; Sohda
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 6 p. 1440 - 1445
反应条件
1: Et3N / toluene / 1 h / 20 °C 2: 18 g / NaOH / propan-2-ol / 6 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 41, # 7 p. 841 - 846
反应条件
1: 67 percent / NaH (oil susp.) / tetrahydrofuran 2: 70 percent / Raney Ni, aq. HCOOH / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1440 - 1445
反应条件
sodium hydroxide; p-toluenesulfonyl chloride; (benzyl)-tri-(butyl)-ammonium chloride 1.) H2O, CH2Cl2, r.t., 2 h; 2.) H2O, 40-50 deg C, 12 h; Yield given. Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1440 - 1445
反应条件
sodium hydroxide in dichloromethane
参考文献
Organic Process Research and Development, , vol. 13, # 6 p. 1190 - 1194
反应条件
1: 64 percent / piperidine / ethanol / Heating 2: acetonitrile / 0.75 h / Irradiation View Scheme
参考文献
Momose; Meguro; Ikeda; Hatanaka; Oi; Sohda
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 6 p. 1440 - 1445
