7-溴-2,3-二氢喹啉-4-酮合成路线 （共 3 条）
反应条件
1: With trifluorormethanesulfonic acid in 1,2-dichloro-ethane T=20°C; 1 h; 2: With sodium hydrogencarbonate in water; 1,2-dichloro-ethane
参考文献
Gomtsyan, Arthur; Bayburt, Erol K.; Schmidt, Robert G.; Lee, Chih-Hung; Brown, Brian S.; Jinkerson, Tammie K.; Koenig, John R.; Daanen, Jerome F.; Latshaw, Steven P.
Patent: US2006/128689 A1, 2006 ;
Location in patent: Page/Page column 55 ;
反应条件
1: pyridine / 0.33 h / Heating 2: aq. HCl / dioxane / 3 h / Heating 3: 1.) PCl5, 2.) AlCl3 / 1.) benzene, from 5 deg C to 23 deg C, 30 min, 2.) benzene 15-20 deg C, 3.5 h 4: 30 percent / gl. AcOH, aq. HCl / 3.5 h / Heating View Scheme
参考文献
Werbel, L. M.; Kesten, S. J.; Turner, W. R.
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 11 p. 837 - 852
反应条件
1: AcOH / 22 h / Heating 2: pyridine / 0.33 h / Heating 3: aq. HCl / dioxane / 3 h / Heating 4: 1.) PCl5, 2.) AlCl3 / 1.) benzene, from 5 deg C to 23 deg C, 30 min, 2.) benzene 15-20 deg C, 3.5 h 5: 30 percent / gl. AcOH, aq. HCl / 3.5 h / Heating View Scheme
参考文献
Werbel, L. M.; Kesten, S. J.; Turner, W. R.
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 11 p. 837 - 852
