7-氟-2,3-二氢喹啉-4-酮合成路线 （共 3 条）
反应条件
1: With trifluorormethanesulfonic acid in 1,2-dichloro-ethane T=20°C; 18 h; 2: With sodium hydrogencarbonate in water; 1,2-dichloro-ethane
参考文献
Schmidt, Robert G.; Bayburt, Erol K.; Latshaw, Steven P.; Koenig, John R.; Daanen, Jerome F.; McDonald, Heath A.; Bianchi, Bruce R.; Zhong, Chengmin; Joshi, Shailen; Honore, Prisca; Marsh, Kennan C.; Lee, Chih-Hung; Faltynek, Connie R.; Gomtsyan, Arthur
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1338 - 1341
反应条件
1: T=130°C; 1.5 h; 2: With sodium hydroxide in water
参考文献
Taisho Pharmaceutical Co. Ltd.
Patent: EP2172453 A1, 2010 ;
Location in patent: Page/Page column 9 ;
EP 2172453 A1
反应条件
1: AcOH / 22 h / Heating 2: pyridine / 0.33 h / Heating 3: aq. HCl / dioxane / 3 h / Heating 4: 1.) PCl5, 2.) AlCl3 / 1.) benzene, from 5 deg C to 23 deg C, 30 min, 2.) benzene 15-20 deg C, 3.5 h 5: 72 percent / gl. AcOH, aq. HCl / 3.5 h / Heating View Scheme
参考文献
Schmidt, Robert G.; Bayburt, Erol K.; Latshaw, Steven P.; Koenig, John R.; Daanen, Jerome F.; McDonald, Heath A.; Bianchi, Bruce R.; Zhong, Chengmin; Joshi, Shailen; Honore, Prisca; Marsh, Kennan C.; Lee, Chih-Hung; Faltynek, Connie R.; Gomtsyan, Arthur
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1338 - 1341
