(R)-n-甲基-1,2,3,4-四氢萘-1-胺合成路线 （共 3 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran Heating / reflux; 2: With sodium hydroxide; water T=20°C; 0.5 h;
参考文献
E. I. DU PONT DE NEMOURS AND COMPANY
Patent: WO2007/14290 A2, 2007 ;
Location in patent: Page/Page column 60 ;
参考文献
Smith, Roger A.; White, Robert L.; Krantz, Allen
Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1558 - 1566
反应条件
1: sodium tris(acetoxy)borohydride / dichloromethane; isopropyl alcohol / 2 h / 20 °C / |Inert atmosphere 2: sodium tris(acetoxy)borohydride / dichloromethane; isopropyl alcohol / 2 h / 20 °C / |Inert atmosphere 3: palladium on activated charcoal; methanol / ethyl acetate / 2 h / 1551.49 Torr / |Inert atmosphere View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BORZILLERI, Robert M.; PEREZ, Heidi L.; WEI, Donna D.; KIM, Kyoung S.
Patent: WO2014/25759 A1, 2014 ;
