4-[(2E)-3-(二甲基氨基)-1-氧代-2-丙烯-1-基]苯甲酸甲酯合成路线 （共 12 条）
反应条件
48 h; HeatingReflux;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2009/100171 A1, 2009 ;
Location in patent: Page/Page column 70-71 ;
反应条件
in N,N-dimethyl acetamide T=105°C; 20 h;
参考文献
DOW AGROSCIENCES LLC; CROUSE, Gary D.; DEMETER, David A.; SPARKS, Thomas C.; WANG, Nick X.; DENT, William Hunter; DEAMICIS, Carl; NIYAZ, Noormohamed M.; BAUM, Erich W.; FISCHER, Lindsey G.; GIAMPIETRO, Natalie C.; FRITZ, Amanda E.
Patent: WO2014/11429 A1, 2014 ;
Location in patent: Page/Page column 50; 51 ;
反应条件
18 h; Heating / reflux;
参考文献
Drewry, David Harold; Jung, David Kendall; Linn, James Andrew; Hunter, Robert Neil; Lee, Dennis; Stavenger, Robert A.; Sehon, Clark
Patent: US2008/275062 A1, 2008 ;
Location in patent: Page/Page column 15-16 ;
参考文献
Tanaka, Akira; Terasawa, Takeshi; Hagihara, Hiroyuki; Sakuma, Yuri; Ishibe, Noriko; Sawada, Masae; Takasugi, Hisashi; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2390 - 2410
反应条件
1: 65 percent / AcOH / 3 h / Ambient temperature 2: 80 percent / DIBAL / CH2Cl2; toluene / 0.5 h / -50 °C 3: 98 percent / MnO2 / acetone / 1 h / Heating View Scheme
参考文献
Tanaka, Akira; Terasawa, Takeshi; Hagihara, Hiroyuki; Sakuma, Yuri; Ishibe, Noriko; Sawada, Masae; Takasugi, Hisashi; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2390 - 2410
反应条件
1: 34 percent / AcOH / 3 h / Ambient temperature 2: 99 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 5 °C 3: 93 percent / MnO2 / acetone / 1 h / Heating View Scheme
参考文献
Tanaka, Akira; Terasawa, Takeshi; Hagihara, Hiroyuki; Sakuma, Yuri; Ishibe, Noriko; Sawada, Masae; Takasugi, Hisashi; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2390 - 2410
反应条件
1: 65 percent / AcOH / 3 h / Ambient temperature 2: 80 percent / DIBAL / CH2Cl2; toluene / 0.5 h / -50 °C View Scheme
参考文献
Tanaka, Akira; Terasawa, Takeshi; Hagihara, Hiroyuki; Sakuma, Yuri; Ishibe, Noriko; Sawada, Masae; Takasugi, Hisashi; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2390 - 2410
反应条件
hydrazine hydrate; acetic acid in methanol 10 h; Ambient temperature;
参考文献
Tanaka, Akira; Terasawa, Takeshi; Hagihara, Hiroyuki; Sakuma, Yuri; Ishibe, Noriko; Sawada, Masae; Takasugi, Hisashi; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2390 - 2410
反应条件
1: 34 percent / AcOH / 3 h / Ambient temperature 2: 99 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 5 °C View Scheme
参考文献
Tanaka, Akira; Terasawa, Takeshi; Hagihara, Hiroyuki; Sakuma, Yuri; Ishibe, Noriko; Sawada, Masae; Takasugi, Hisashi; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2390 - 2410
反应条件
acetic acid 3 h; Ambient temperature;
参考文献
Tanaka, Akira; Terasawa, Takeshi; Hagihara, Hiroyuki; Sakuma, Yuri; Ishibe, Noriko; Sawada, Masae; Takasugi, Hisashi; Tanaka, Hirokazu
Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2390 - 2410
