hydrogenchloride in 1,4-dioxane

sodium hydride in 1,4-dioxane T=80 - 90°C; 4 h;

1: potassium carbonate / acetone / 48 h / 20 °C / Inert atmosphere 2: potassium tert-butylate / tert-butyl alcohol / 24 h / 70 °C View Scheme

1: potassium carbonate / acetone / 24 h / 20 °C 2: caesium carbonate / 2-methyl tetrahydrofuran / 10 h / 40 °C 3: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 4: N-bromosuccinmide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor View Scheme

1: potassium carbonate / acetone / 24 h / 20 °C 2: caesium carbonate / 2-methyl tetrahydrofuran / 10 h / 40 °C 3: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 4: N-bromosuccinmide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor 5: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux View Scheme

1: potassium carbonate / acetone / 48 h / 20 °C / Inert atmosphere 2: potassium tert-butylate / tert-butyl alcohol / 24 h / 70 °C 3: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 4: N-bromosuccinmide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation 5: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere View Scheme

1: potassium carbonate / acetone / 24 h / 20 °C 2: caesium carbonate / 2-methyl tetrahydrofuran / 10 h / 40 °C 3: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 4: N-bromosuccinmide / acetonitrile / 0.5 h / UV-irradiation; Inert atmosphere; Sealed flow reactor 5: sodium hydrogencarbonate; water / acetonitrile / 4 h / Reflux 6: acetic anhydride; dimethyl sulfoxide / 85 °C View Scheme

1: potassium carbonate / acetone / 48 h / 20 °C / Inert atmosphere 2: potassium tert-butylate / tert-butyl alcohol / 24 h / 70 °C 3: triethylamine / dichloromethane / 8 h / -5 °C / Inert atmosphere 4: N-bromosuccinmide / acetonitrile / 16 h / 20 °C / Inert atmosphere; UV-irradiation 5: sodium hydrogencarbonate; dimethyl sulfoxide; sodium iodide / 71 h / 20 °C / Inert atmosphere View Scheme

1: potassium carbonate / acetone / 4.17 h / 20 °C 2: sodium hydride / tetrahydrofuran; mineral oil / 48 h / 25 °C 3: triethylamine / dichloromethane / 17 h / -5 °C / Inert atmosphere 4: Oxonereg;; sodium hydrogencarbonate / tetrabutyl-ammonium chloride / dichloromethane; water; acetone / 16 h / 0 - 20 °C 5: 1,4-diaza-bicyclo[2.2.2]octane / 1,4-dioxane / 24 h / 40 °C 6: acetic anhydride; dimethyl sulfoxide / 24 h / 20 °C View Scheme

hydrogenchloride in ethanol; isopropyl alcohol 40 h; Heating / reflux; Product distribution / selectivity;