1-[(1R)-3-氯-1-苯基丙氧基]-2-甲基苯合成路线 （共 10 条）
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran Mitsunobu reaction;
参考文献
Lapis, Alexandre A. M.; De Fatima, Angelo; Martins, Jose E. D.; Costa, Valentim E. U.; Pilli, Ronaldo A.
Tetrahedron Letters, 2005 , vol. 46, # 3 p. 495 - 498
反应条件
triphenylphosphine in tetrahydrofuran; pentane
参考文献
Aldrich-Boranes, Inc.
Patent: US4868344 A1, 1989 ;
反应条件
1: 65 percent / BH3*Me2S / (1S,2S,3R,4R)-3-amino-7,7-dimethoxynorbornan-2-ol / tetrahydrofuran / 2 h / 25 °C 2: 75 percent / Ph3P; DEAD / tetrahydrofuran View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 3 p. 495 - 498
反应条件
1: 93 percent / pyridine; DMAP / CH2Cl2 / 0 - 20 °C 2: aq. phosphate buffer; Novozyme 435 / 288 h / 30 °C / pH 7 3: 57 percent / PPh3; diethyl azodicarboxylate / tetrahydrofuran / 20 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1, , # 11 p. 1767 - 1769
反应条件
1: AlCl3, aluminium chloride / 0.5 h / 0 - 50 °C 2: Candida tenuis xylose reductase; Reduced nicotinamide-adenine dinucleotide; potassium phosphate / methanol / 24 h 3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 16 h / 20 °C View Scheme
参考文献
Chirality, , vol. 24, # 10 p. 847 - 853,7
反应条件
1: aq. phosphate buffer; Novozyme 435 / 288 h / 30 °C / pH 7 2: 57 percent / PPh3; diethyl azodicarboxylate / tetrahydrofuran / 20 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1, , # 11 p. 1767 - 1769
反应条件
2: 100 percent / K2CO3, MeOH 3: Ph3P, diethylazodicarboxylate View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 3, # 4 p. 525 - 528
反应条件
1: 100 percent / K2CO3, MeOH 2: Ph3P, diethylazodicarboxylate View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 3, # 4 p. 525 - 528
反应条件
in ethanol; water T=130°C;
参考文献
Lapis, Alexandre A. M.; De Fatima, Angelo; Martins, Jose E. D.; Costa, Valentim E. U.; Pilli, Ronaldo A.
Tetrahedron Letters, 2005 , vol. 46, # 3 p. 495 - 498
反应条件
in ethanol; water T=130°C; 3 h;
参考文献
Srebnik, Morris; Ramachandran, P.V.; Brown, Herbert C.
Journal of Organic Chemistry, 1988 , vol. 53, # 13 p. 2916 - 2920
