3-脱氧-5-o-(二甲氧基三苯甲游基)-5-甲基尿苷合成路线 （共 9 条）
反应条件
acetic acid T=22°C; 0.5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 7 p. 1475 - 1479
参考文献
Rejman, Dominik; Masojidkova, Milena; Rosenberg, Ivan
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 11 p. 1683 - 1705
反应条件
1: pyridine / 1.5 h
2: pyridine / CH2Cl2 / 1) ice-bath, 15 min; 2) 20 deg C, 3 h
3: aq. NaOH / ethanol / 1 h / 60 °C
4: 75 percent / LiEt3BH / tetrahydrofuran / 1) dry ice/acetone cooling, 1 h; 2) 20 deg C, 1 h
View Scheme
参考文献
Webb; Mitsuya; Broder
Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1475 - 1479
反应条件
1: pyridine / CH2Cl2 / 1) ice-bath, 15 min; 2) 20 deg C, 3 h
2: aq. NaOH / ethanol / 1 h / 60 °C
3: 75 percent / LiEt3BH / tetrahydrofuran / 1) dry ice/acetone cooling, 1 h; 2) 20 deg C, 1 h
View Scheme
参考文献
Webb; Mitsuya; Broder
Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1475 - 1479
反应条件
1: pyridine / 1.5 h
2: pyridine / CH2Cl2 / 1) ice-bath, 15 min; 2) 20 deg C, 3 h
3: aq. NaOH / ethanol / 1 h / 60 °C
4: 75 percent / LiEt3BH / tetrahydrofuran / 1) dry ice/acetone cooling, 1 h; 2) 20 deg C, 1 h
View Scheme
参考文献
Webb; Mitsuya; Broder
Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1475 - 1479
反应条件
1: 40 percent / tin tetrachloride / acetonitrile / 20 h / 20 °C
2: 71 percent / hydrogen chloride / methanol / 3 h / 20 °C
3: mesyl chloride; pyridine
4: Dowex 50 OH(1-) form / methanol
5: 99 percent / pyridine / 20 °C
View Scheme
参考文献
Rejman, Dominik; Masojidkova, Milena; Rosenberg, Ivan
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 11 p. 1683 - 1705
反应条件
1: mesyl chloride; pyridine
2: Dowex 50 OH(1-) form / methanol
3: 99 percent / pyridine / 20 °C
View Scheme
参考文献
Rejman, Dominik; Masojidkova, Milena; Rosenberg, Ivan
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 11 p. 1683 - 1705
反应条件
1: 71 percent / hydrogen chloride / methanol / 3 h / 20 °C
2: mesyl chloride; pyridine
3: Dowex 50 OH(1-) form / methanol
4: 99 percent / pyridine / 20 °C
View Scheme
参考文献
Rejman, Dominik; Masojidkova, Milena; Rosenberg, Ivan
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 11 p. 1683 - 1705
反应条件
1: 40 percent / tin tetrachloride / acetonitrile / 20 h / 20 °C
2: 71 percent / hydrogen chloride / methanol / 3 h / 20 °C
3: mesyl chloride; pyridine
4: Dowex 50 OH(1-) form / methanol
5: 99 percent / pyridine / 20 °C
View Scheme
参考文献
Rejman, Dominik; Masojidkova, Milena; Rosenberg, Ivan
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 11 p. 1683 - 1705
