1: 84 percent / tert-butyl hydroperoxide (70percent), vanadyl acetylacetonate / H2O; CH2Cl2 / 6 h / Ambient temperature 2: 81 percent / aq. sodium hydroxide (1percent) / 2.5 h / 70 °C 3: 72 percent / CH2Cl2; pyridine / 6 h / -10 °C 4: 99 percent / potassium carbonate (K2CO3) / methanol / 0.5 h / Ambient temperature 5: 95 percent / H2 / Pd-C (5percent) / ethyl acetate 6: 86 percent / potassium carbonate (K2CO3) / methanol / 0.5 h / Ambient temperature 7: 1.) sodium hydride (NaH) / 1.) THF, 0 deg C, 1 h; 2.) THF, room temp., 1 h 8: 76 percent / HCl (2N) / methanol / 2 h / Ambient temperature View Scheme

With  tert.-butylhydroperoxide; vanadyl acetylacetonate in  dichloromethane; water 6 h;  Ambient temperature;   

Multi-step reaction with 2 steps 1: 84 percent / tert-butyl hydroperoxide (70percent), vanadyl acetylacetonate / H2O; CH2Cl2 / 6 h / Ambient temperature2: 81 percent / aq. sodium hydroxide (1percent) / 2.5 h / 70 °C  

Multi-step reaction with 3 steps 1: 84 percent / tert-butyl hydroperoxide (70percent), vanadyl acetylacetonate / H2O; CH2Cl2 / 6 h / Ambient temperature2: 81 percent / aq. sodium hydroxide (1percent) / 2.5 h / 70 °C3: 72 percent / CH2Cl2; pyridine / 6 h / -10 °C  

Multi-step reaction with 5 steps 1: 84 percent / tert-butyl hydroperoxide (70percent), vanadyl acetylacetonate / H2O; CH2Cl2 / 6 h / Ambient temperature2: 81 percent / aq. sodium hydroxide (1percent) / 2.5 h / 70 °C3: 72 percent / CH2Cl2; pyridine / 6 h / -10 °C4: 99 percent / potassium carbonate (K2CO3) / methanol / 0.5 h / Ambient temperature5: 95 percent / H2 / Pd-C (5percent) / ethyl acetate  

Multi-step reaction with 4 steps 1: 84 percent / tert-butyl hydroperoxide (70percent), vanadyl acetylacetonate / H2O; CH2Cl2 / 6 h / Ambient temperature2: 81 percent / aq. sodium hydroxide (1percent) / 2.5 h / 70 °C3: 72 percent / CH2Cl2; pyridine / 6 h / -10 °C4: 99 percent / potassium carbonate (K2CO3) / methanol / 0.5 h / Ambient temperature  

Multi-step reaction with 7 steps 1: 84 percent / tert-butyl hydroperoxide (70percent), vanadyl acetylacetonate / H2O; CH2Cl2 / 6 h / Ambient temperature2: 81 percent / aq. sodium hydroxide (1percent) / 2.5 h / 70 °C3: 72 percent / CH2Cl2; pyridine / 6 h / -10 °C4: 99 percent / potassium carbonate (K2CO3) / methanol / 0.5 h / Ambient temperature5: 95 percent / H2 / Pd-C (5percent) / ethyl acetate6: 86 percent / potassium carbonate (K2CO3) / methanol / 0.5 h / Ambient temperature7: 1.) sodium hydride (NaH) / 1.) THF, 0 deg C, 1 h; 2.) THF, room temp., 1 h