甲基3-甲基环戊烯-1-羧酸酯合成路线 （共 3 条）
反应条件
1: DIBAH / toluene / -78 °C
2: NaH / tetrahydrofuran / 0 °C
3: 1.) O3; 2.) Me2S / 1.) CH2Cl2, -78 deg C; 2.) reflux
4: NaOH / methanol / Heating
5: DIBAH / diethyl ether / -100 °C
6: Et2Zn / toluene / 60 °C
7: PCC / CH2Cl2
8: tetrahydrofuran
View Scheme
参考文献
Gadwood; Lett; Wissinger
Journal of the American Chemical Society, 1984 , vol. 106, # 13 p. 3869 - 3870
反应条件
1.1: potassium hydroxide / methanol; water / 8 h / 60 °C
1.2: 20 °C / pH 1
2.1: sulfuric acid / dichloromethane; water / 16 h / 0 °C
View Scheme
参考文献
Abraham, Elin; Claridge, Timothy D.W.; Davies, Stephen G.; Odell, Barbara; Roberts, Paul M.; Russell, Angela J.; Smith, Andrew D.; Smith, Lorna J.; Storr, Helen R.; Sweet, Miles J.; Thompson, Amber L.; Thomson, James E.; Tranter, George E.; Watkin, David J.
Tetrahedron Asymmetry, 2011 , vol. 22, # 1 p. 69 - 100
反应条件
Multi-step reaction with 7 steps 1: DIBAH / toluene / -78 °C2: NaH / tetrahydrofuran / 0 °C3: 1.) O3; 2.) Me2S / 1.) CH2Cl2, -78 deg C; 2.) reflux4: NaOH / methanol / Heating5: DIBAH / diethyl ether / -100 °C6: Et2Zn / toluene / 60 °C7: PCC / CH2Cl2
参考文献
Gadwood; Lett; Wissinger Journal of the American Chemical Society, 1984 , vol. 106, # 13 p. 3869 - 3870
