hydrogenchloride in 1,4-dioxane; dichloromethane T=20°C; 2 h;

1: isopropyl acetate, aq. potassium bicarbonate / 5 °C 2: 60 °C 3: 83 percent / 1.) tributylphosphine, diisopropylazodicarboxylate; 2.) ethanolic HCl / ethyl acetate / 0 - 5 °C View Scheme

1: 60 °C 2: 83 percent / 1.) tributylphosphine, diisopropylazodicarboxylate; 2.) ethanolic HCl / ethyl acetate / 0 - 5 °C View Scheme