反应条件
1: 3,5-bis(trifluoromethyl)phenyl bromide With isopropylmagnesium chloride in tetrahydrofuran T=0°C; 1 h; Inert atmosphere; 2: 1-ethyl methyl (2R)-pyrrolidine-1,2-dicarboxylate in tetrahydrofuran T=0 - 65°C; Inert atmosphere;
参考文献
Zhou, Jiacheng; Liu, Pingli; Lin, Qiyan; Metcalf, Brian W.; Meloni, David; Pan, Yongchun; Xia, Michael; Li, Mei; Yue, Tai-Yuen; Rodgers, James D.; Wang, Haisheng
Patent: US2010/190981 A1, 2010 ;
Location in patent: Page/Page column 67-68 ;
US 20100190981 A1