1: tetrahydrofuran / -15 - 10 °C 2: sodium hydroxide / tetrahydrofuran / 50 °C 3: sodium hydrogencarbonate; 1,4-di(diphenylphosphino)-butane / palladium diacetate / 1,1-dimethylpropan-1-ol / 35 - 100 °C / Reflux 4: hydrogen / palladium 10 on activated carbon / methanol / 60 °C / 3102.97 Torr View Scheme

Multi-step reaction with 2 steps 1: tetrahydrofuran / -15 - 10 °C2: sodium hydroxide / tetrahydrofuran / 50 °C  

Multi-step reaction with 3 steps 1: tetrahydrofuran / -15 - 10 °C2: sodium hydroxide / tetrahydrofuran / 50 °C3: sodium hydrogencarbonate; 1,4-di(diphenylphosphino)-butane / palladium diacetate / 1,1-dimethylpropan-1-ol / 35 - 100 °C / Reflux