3-(3-氟-4-甲基苯基)-1,2,4-噁二唑合成路线 (共 3 条)
反应条件
1: With boron trifluoride diethyl etherate in dichloromethane T=20 - 45°C; 19.5 h; 2: With hydrogenchloride in dichloromethane; water Product distribution / selectivity;
参考文献
Bristol-Myers Squibb Company
Patent: US2009/111858 A1, 2009 ;
Location in patent: Page/Page column 6; 17 ;
反应条件
1: With Sodium bromate in water; ethyl acetate
T=20°C;
2: With sodium hydrogensulfite in water; ethyl acetate
T=20°C; 2 h; Product distribution / selectivity;
参考文献
Bristol-Myers Squibb Company
Patent: US2009/111858 A1, 2009 ;
Location in patent: Page/Page column 18 ;
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in acetonitrile
T=20 - 70°C; 2 h; Product distribution / selectivity;
参考文献
Bristol-Myers Squibb Company
Patent: US2009/111858 A1, 2009 ;
Location in patent: Page/Page column 18 ;