3-[4-(溴甲基)-3-氟苯基]-1,2,4-噁二唑合成路线 (共 4 条)
反应条件
hydroxylamine; tetra-(n-butyl)ammonium iodide; caesium carbonate in acetonitrile T=15 - 35°C; Product distribution / selectivity;
参考文献
Bristol-Myers Squibb Company
Patent: US2009/111858 A1, 2009 ;
Location in patent: Page/Page column 21-22 ;
反应条件
1: With N-ethyl-N,N-diisopropylamine in tetrahydrofuran
T=0°C; 0.25 h;
2: With phosphonic acid diethyl ester in tetrahydrofuran
T=20°C; 1 h; Product distribution / selectivity;
参考文献
Bristol-Myers Squibb Company
Patent: US2009/111858 A1, 2009 ;
Location in patent: Page/Page column 6; 18 ;
反应条件
1: With Sodium bromate in water; ethyl acetate
T=20°C;
2: With sodium hydrogensulfite in water; ethyl acetate
T=20°C; 2 h; Product distribution / selectivity;
参考文献
Bristol-Myers Squibb Company
Patent: US2009/111858 A1, 2009 ;
Location in patent: Page/Page column 18 ;
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in acetonitrile
T=20 - 70°C; 2 h; Product distribution / selectivity;
参考文献
Bristol-Myers Squibb Company
Patent: US2009/111858 A1, 2009 ;
Location in patent: Page/Page column 18 ;