(2R)-2-[[(4-氯苯基)磺酰基]氨基]-5,5,5-三氟-戊酰胺合成路线 （共 6 条）
反应条件
triethylamine in tetrahydrofuran T=15 - 25°C; 0.833333 h; Product distribution / selectivity;
参考文献
Bristol-Myers Squibb Company
Patent: US2010/240719 A1, 2010 ;
Location in patent: Page/Page column 12; 13 ;
反应条件
ammonium hydroxide in 2-methyl tetrahydrofuran; water
参考文献
Hanson, Ronald L.; Johnston, Robert M.; Goldberg, Steven L.; Parker, William L.; Goswami, Animesh
Organic Process Research and Development, 2013 , vol. 17, # 4 p. 693 - 700
反应条件
1: sodium hydroxide / water / 13 h / pH 10.3 - 10.7 / |Large scale 2: oxalyl dichloride / 2-methyl tetrahydrofuran / 0.5 h 3: ammonium hydroxide / water; 2-methyl tetrahydrofuran View Scheme
参考文献
Hanson, Ronald L.; Johnston, Robert M.; Goldberg, Steven L.; Parker, William L.; Goswami, Animesh
Organic Process Research and Development, 2013 , vol. 17, # 4 p. 693 - 700
反应条件
1: D-glucose; NADP; D-AADH and GDH enzyme mixture from E. coli gdhAminus cells; sodium hydroxide; ammonium chloride / water / 20 h / 30 °C / pH 9 / |Enzymatic reaction 2: sodium hydroxide / water / 13 h / pH 10.3 - 10.7 / |Large scale 3: oxalyl dichloride / 2-methyl tetrahydrofuran / 0.5 h 4: ammonium hydroxide / water; 2-methyl tetrahydrofuran View Scheme
参考文献
Hanson, Ronald L.; Johnston, Robert M.; Goldberg, Steven L.; Parker, William L.; Goswami, Animesh
Organic Process Research and Development, 2013 , vol. 17, # 4 p. 693 - 700
反应条件
hydroxylamine; tetra-(n-butyl)ammonium iodide; caesium carbonate in acetonitrile T=15 - 35°C; Product distribution / selectivity;
参考文献
Bristol-Myers Squibb Company
Patent: US2009/111858 A1, 2009 ;
Location in patent: Page/Page column 21-22 ;
反应条件
caesium carbonate in N,N-dimethyl-formamide T=20°C; 2 h; Product distribution / selectivity;
参考文献
Bristol-Myers Squibb Company
Patent: US2009/111858 A1, 2009 ;
Location in patent: Page/Page column 4; 19 ;
