反应条件
1: pyridine / 1.5 h 2: pyridine / CH2Cl2 / 1) ice-bath, 15 min; 2) 20 deg C, 3 h 3: aq. NaOH / ethanol / 1 h / 60 °C 4: 75 percent / LiEt3BH / tetrahydrofuran / 1) dry ice/acetone cooling, 1 h; 2) 20 deg C, 1 h 5: 74 percent / aq. AcOH / 0.5 h / 22 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 7 p. 1475 - 1479
