N-CBZ-(二乙氧基磷酸基)氨基酸甲酯合成路线 （共 11 条）
反应条件
1: N-Cbz-amino-methoxyglycinate With phosphorus tribromide in toluene T=70°C; 20 h; 2: diethylphosphoric acid ethyl ester in toluene T=70°C; 2 h;
参考文献
HUTCHISON MEDIPHARMA LIMITED; SU, Wei-guo; DAI, Guangxiu; XIAO, Kun; JIA, Hong; ZHANG, Zhulin; VENABLE, Jennifer Diane; BEMBENEK, Scott Damian; CHAI, Wenying
Patent: WO2014/15830 A1, 2014 ;
Location in patent: Page/Page column 136; 137 ;
反应条件
boron trifluoride diethyl etherate in dichloromethane T=-10 - 25°C;
参考文献
Ku, Bonchul; Oh, Dong Young
Tetrahedron Letters, 1988 , vol. 29, # 35 p. 4465 - 4466
反应条件
1.1: 80 percent / H2SO4 / 48 h / 20 °C 2.1: PCl3 / toluene / 70 °C 2.2: 66 percent / toluene / 2 h / 70 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 12 p. 2385 - 2388
反应条件
1.1: 55 percent / diethyl ether / 16 h 2.1: 80 percent / H2SO4 / 48 h / 20 °C 3.1: PCl3 / toluene / 70 °C 3.2: 66 percent / toluene / 2 h / 70 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 12 p. 2385 - 2388
反应条件
boron trifluoride diethyl etherate in dichloromethane T=-10 - 25°C;
参考文献
Ku, Bonchul; Oh, Dong Young
Tetrahedron Letters, 1988 , vol. 29, # 35 p. 4465 - 4466
反应条件
1: PCl3 / toluene / 18 h / 70 °C 2: toluene / 2 h / 70 °C View Scheme
参考文献
Archiv der Pharmazie, , vol. 329, # 11 p. 503 - 509
反应条件
in toluene T=70°C; 2 h; Yield given;
参考文献
Archiv der Pharmazie, , vol. 329, # 11 p. 503 - 509
反应条件
boron trifluoride diethyl etherate 1.) THF, -10 deg C, 5 min. ; 2.) TBAF, from -10 deg C to RT; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 29, # 35 p. 4465 - 4466
反应条件
1: palladium 10 on activated carbon; hydrogen / methanol / Inert atmosphere 2: pyridine / -5 - 9 °C / Inert atmosphere View Scheme
参考文献
Sun, De-Qun; Sun, Li; Luo, Min
Asian Journal of Chemistry, 2012 , vol. 24, # 4 p. 1731 - 1734
反应条件
piperidine in water
6 h; Ambient temperature;
参考文献
Shankar; Scott
Tetrahedron Letters, 1993 , vol. 34, # 2 p. 231 - 234
