4-(2-甲基-6-苯基吡咯并[2,3-e]嘧啶-4-基)吗啉合成路线 （共 5 条）
反应条件
potassium carbonate in water
T=120°C; 4 h;
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
potassium carbonate in water
4 h;
参考文献
Modnikova, G. A.; Titkova, R. M.; Glushkov, R. G.; Sokolova, A. S.; Silin, V. A.; Chernov, V. A.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 2 p. 135 - 141
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 2 p. 185 - 191
反应条件
1.1: NaOEt / ethanol / 0.5 h / 20 °C
1.2: 44 percent / ethanol / 20 °C
2.1: 15 percent / NaOEt / 0.33 h / 360 °C
3.1: 44 percent / POCl3; N,N-diethylaniline / 1,2-dichloro-ethane / 3 h / Heating
4.1: 33 percent / K2CO3 / H2O / 4 h / 120 °C
View Scheme
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
1: 15 percent / NaOEt / 0.33 h / 360 °C
2: 44 percent / POCl3; N,N-diethylaniline / 1,2-dichloro-ethane / 3 h / Heating
3: 33 percent / K2CO3 / H2O / 4 h / 120 °C
View Scheme
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
1: 44 percent / POCl3; N,N-diethylaniline / 1,2-dichloro-ethane / 3 h / Heating
2: 33 percent / K2CO3 / H2O / 4 h / 120 °C
View Scheme
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
