7-溴喹唑啉-2.4(1H.3H)-二酮合成路线 （共 7 条）
反应条件
acetic acid T=20°C; 22 h;
参考文献
MERCK PATENT GMBH; Mederski, Werner; Fuchss, Thomas; Zenke, Frank
Patent: US2013/12489 A1, 2013 ;
Location in patent: Paragraph 0173 ;
参考文献
ENDO PHARMACEUTICALS INC.; SMITH, Roger, Astbury; THOMPSON, Scott, Kevin; HOSAHALLI, Subramanya; BEJUGAM, Mallesham; NANDURI, Srinivas; PANIGRAHI, Sunil, Kumar; MAHALINGAM, Natarajan
Patent: WO2012/58671 A1, 2012 ;
Location in patent: Page/Page column 92 ;
参考文献
Endo Pharmaceuticals Inc.; Smith, Roger Astbury; Venkatesan, Aranapakam; Bejugam, Mallesham; Hoshalli, Subramanya; Nanduri, Srinivas
Patent: US2014/38952 A1, 2014 ;
Location in patent: Page/Page column 0158-0159 ;
反应条件
1.1: hydroxylamine hydrochloride; sodium sulfate; 1-[4-(4-methyl-piperazine-1-carbonyl)-phenyl]-3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-urea / 2 h / 90 °C 2.1: sulfuric acid / 3 h / 90 °C 3.1: sodium hydroxide; dihydrogen peroxide / water / 2 h / 0 °C 3.2: 0 °C / pH 6 4.1: 3 h / 195 °C View Scheme
反应条件
1.1: sodium hydroxide; dihydrogen peroxide / water / 2 h / 0 °C 1.2: 0 °C / pH 6 2.1: 3 h / 195 °C View Scheme
反应条件
1.1: sulfuric acid / 3 h / 90 °C 2.1: sodium hydroxide; dihydrogen peroxide / water / 2 h / 0 °C 2.2: 0 °C / pH 6 3.1: 3 h / 195 °C View Scheme
反应条件
N-ethyl-N,N-diisopropylamine; trichlorophosphate T=20°C; 36 h; Reflux;
参考文献
MERCK PATENT GMBH; Mederski, Werner; Fuchss, Thomas; Zenke, Frank
Patent: US2013/12489 A1, 2013 ;
Location in patent: Paragraph 0174 ;
