(2-吗啉-4-基-2-氧代乙基)-氨基甲酸叔丁酯合成路线 （共 4 条）
反应条件
1: BOC-glycine With triphenylphosphine in dichloromethane; ethyl acetate T=0°C; 0.5 h; 2: morpholine With N-ethyl-N,N-diisopropylamine in dichloromethane; ethyl acetate T=20°C; 12 h;
参考文献
SENTINEL ONCOLOGY LIMITED; BOYLE, Robert George; BOYCE, Richard Justin
Patent: WO2013/72502 A1, 2013 ;
Location in patent: Page/Page column 81 ;
参考文献
Anderson; Flaherty; Swarbrick
Journal of Organic Chemistry, 2000 , vol. 65, # 26 p. 9152 - 9156
反应条件
hydrogenchloride in 1,4-dioxane; methanol T=10 - 20°C;
参考文献
SENTINEL ONCOLOGY LIMITED; BOYLE, Robert George; BOYCE, Richard Justin
Patent: WO2013/72502 A1, 2013 ;
Location in patent: Page/Page column 81; 82 ;
反应条件
hydrogenchloride in ethyl acetate Ambient temperature;
参考文献
Venuti, Michael C.; Alvarez, Robert; Bruno, John J.; Strosberg, Arthur M.; Gu, Leo; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2145 - 2152
