(2-溴-6-硝基苄氧基)(叔丁基)二甲基硅烷合成路线 （共 4 条）
反应条件
lithium hydroxide hydrate in tetrahydrofuran; ethanol; water T=20°C; 1 h; Inert atmosphere;
参考文献
GILEAD CONNECTICUT, INC.; GENENTECH, INC.; CURRIE, Kevin S.; WANG, Xiaojing; YOUNG, Wendy B.
Patent: WO2012/31004 A1, 2012 ;
Location in patent: Page/Page column 88-89 ;
WO 2012/031004 A1
反应条件
triethylamine in dichloromethane T=20°C;
参考文献
Roche Palo Alto LLC
Patent: US2009/105209 A1, 2009 ;
Location in patent: Page/Page column 62 ;
US 20090105209 A1
反应条件
1: potassium acetate / N,N-dimethyl-formamide / 0.5 h / 70 °C / Inert atmosphere 2: lithium hydroxide hydrate / ethanol; water; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere View Scheme
参考文献
GILEAD CONNECTICUT, INC.; GENENTECH, INC.; CURRIE, Kevin S.; WANG, Xiaojing; YOUNG, Wendy B.
Patent: WO2012/31004 A1, 2012 ;
WO 2012/031004 A1
反应条件
1: 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / tetrachloromethane / 16 h / 80 °C / Reflux 2: potassium acetate / N,N-dimethyl-formamide / 0.5 h / 70 °C / Inert atmosphere 3: lithium hydroxide hydrate / ethanol; water; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere View Scheme
参考文献
GILEAD CONNECTICUT, INC.; GENENTECH, INC.; CURRIE, Kevin S.; WANG, Xiaojing; YOUNG, Wendy B.
Patent: WO2012/31004 A1, 2012 ;
WO 2012/031004 A1
