6-羟基-2-氮杂螺[3.3]庚烷-2-甲酸叔丁酯合成路线 （共 4 条）
反应条件
sodium tetrahydroborate in methanol T=0°C; 0.5 h; Inert atmosphere;
参考文献
BETA PHARMA CANADA INC.; WANG, Zhaoyin; LI, Lianhai; WANG, Zhigang
Patent: WO2013/13308 A1, 2013 ;
Location in patent: Paragraph 00178-00180 ;
WO 2013/013308 A1
反应条件
cyclohexa-1,4-diene; Pearlman's catalist in methanol 48 h; Reflux;
参考文献
Organic Letters, , vol. 11, # 16 p. 3523 - 3525
反应条件
1: zinc / diethyl ether / 14 h / 10 - 30 °C / Inert atmosphere 2: zinc; acetic acid / 1,4-dioxane / 16 h / 0 - 20 °C 3: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C View Scheme
反应条件
Dess-Martin periodane in dichloromethane 0.666667 h;
参考文献
Meyers, Marvin J.; Muizebelt, Inouk; Van Wiltenburg, Jim; Brown, David L.; Thorarensen, Atli
Organic Letters, 2009 , vol. 11, # 16 p. 3523 - 3525
