2-丁基-1H-咪唑-4,5-二甲腈合成路线 （共 8 条）
反应条件
pyridine in hexane; ethyl acetate
参考文献
US5128355 A1, ;
US 5128355 A
参考文献
US5616599 A1, ;
US 5616599 A
反应条件
1.) CH3CN, reflux, 5 h, 2.) xylene, reflux, 7 h;
参考文献
Yanagisawa, Hiroaki; Amemiya, Yoshiya; Kanazaki, Takuro; Shimoji, Yasuo; Fujimoto, Koichi; Kitahara, Yoshiko; Sada, Toshio; Mizuno, Makoto; Ikeda, Masahiro; Miyamoto, Shuichi; Furukawa, Youji; Koike, Hiroyuki
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 323 - 338
参考文献
US5616599 A1, ;
US 5616599 A
反应条件
1: 49 percent / acetonitrile / 3 h / -30 deg C to room temperature 2: 1) nBuLi, 2) 2 N HCl / 1) THF, n-hexane, 30 min, room temperature View Scheme
参考文献
Chemische Berichte, , vol. 124, # 4 p. 699 - 705
反应条件
hydrogenchloride; n-butyllithium 1) THF, n-hexane, 30 min, room temperature; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Chemische Berichte, , vol. 124, # 4 p. 699 - 705
反应条件
hydrogenchloride 1) THF, n-hexane, 30 min, room temperature; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Chemische Berichte, , vol. 124, # 4 p. 699 - 705
反应条件
hydrogenchloride
8 h; Heating;
参考文献
Yanagisawa, Hiroaki; Amemiya, Yoshiya; Kanazaki, Takuro; Shimoji, Yasuo; Fujimoto, Koichi; Kitahara, Yoshiko; Sada, Toshio; Mizuno, Makoto; Ikeda, Masahiro; Miyamoto, Shuichi; Furukawa, Youji; Koike, Hiroyuki
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 323 - 338
