4-甲基-[1,1-联苯]-3-羧酸甲酯合成路线 （共 10 条）
反应条件
Merrifield resin-bound dicyclohexylphosphinobiphenyl ligand; caesium carbonate; tris(dibenzylideneacetone)dipalladium (0) in tetrahydrofuran T=65°C; Suzuki reaction;
参考文献
Parrish; Buchwald
Journal of Organic Chemistry, 2001 , vol. 66, # 11 p. 3820 - 3827
反应条件
copper T=210°C; 1 h;
参考文献
Carini, David J.; Duncia, John V.; Johnson, Alexander L.; Chiu, Andrew T.; Price, William A.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1330 - 1336
反应条件
potassium carbonate in ethanol; water T=20°C; Suzuki-Miyaura coupling; 6 h;
参考文献
Sreedhar; Yada, Divya; Reddy, P. Surendra
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 14-15 p. 2823 - 2836
反应条件
tripotassium phosphate monohydrate; 1-methyl-2-(2-(dicyclohexylphosphino)phenyl)-1H-benzoimidazole; bis(dibenzylideneacetone)-palladium(0) in toluene; tert-butyl alcohol T=135°C; Suzuki coupling; 24 h; Inert atmosphere;
参考文献
Wong, Shun Man; So, Chau Ming; Chung, Kin Ho; Luk, Chi Him; Lau, Chak Po; Kwong, Fuk Yee
Tetrahedron Letters, 2012 , vol. 53, # 29 p. 3754 - 3757
反应条件
bis-triphenylphosphine-palladium(II) chloride; lithium chloride in N,N-dimethyl-formamide Inert atmosphere;
参考文献
Sanchez, Ana I.; Martinez-Barrasa, Valentin; Burgos, Carolina; Vaquero, Juan J.; Alvarez-Builla, Julio; Terricabras, Emma; Segarra, Victor
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 8 p. 2370 - 2378
反应条件
1: PdCl2; aq. NaOH 2: benzene; methanol; hexane View Scheme
参考文献
Paul, Gitendra C.; De Clercq, Erik; Pannecouque, Christophe; Witvrouw, Myriam; Loftus, Tracy L.; Turpin, Jim A.; Buckheit Jr., Robert W.; Cushman, Mark
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 18 p. 2149 - 2152
反应条件
1: PdCl2; aq. NaOH 2: benzene; methanol; hexane View Scheme
参考文献
Paul, Gitendra C.; De Clercq, Erik; Pannecouque, Christophe; Witvrouw, Myriam; Loftus, Tracy L.; Turpin, Jim A.; Buckheit Jr., Robert W.; Cushman, Mark
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 18 p. 2149 - 2152
反应条件
1: With potassium phosphate; Ni(PCy3)2Br2 in tetrahydrofuran T=20°C; Suzuki coupling; Inert atmosphere; 2: With water in tetrahydrofuran T=20°C; Suzuki coupling;
参考文献
Xing, Chun-Hui; Lee, Jeng-Ru; Tang, Zhen-Yu; Zheng, Jin Rong; Hu, Qiao-Sheng
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 11-12 p. 2051 - 2059
反应条件
methanol in hexane; benzene Methylation;
参考文献
Santhosh; Paul; De Clercq; Pannecouque; Witvrouw; Loftus; Turpin; Buckheit, Jr.; Cushman
Journal of Medicinal Chemistry, 2001 , vol. 44, # 5 p. 703 - 714
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; potassium phosphate; n-butyllithium; 1,1'-bis(diphenylphosphanyl)ferrocenenickel(II) chloride; potassium iodide 1.) toluene, room temperature, 30 min, 2.) toluene, 80 deg C, 16 h; Yield given. Multistep reaction;
参考文献
Ueda, Masato; Saitoh, Atsushi; Oh-tani, Saori; Miyaura, Norio
Tetrahedron, 1998 , vol. 54, # 43 p. 13079 - 13086
