4'-甲基联苯-2-羧酸甲酯合成路线 （共 42 条）
反应条件
bis-triphenylphosphine-palladium(II) chloride; lithium chloride in N,N-dimethyl-formamide Inert atmosphere;
参考文献
Sanchez, Ana I.; Martinez-Barrasa, Valentin; Burgos, Carolina; Vaquero, Juan J.; Alvarez-Builla, Julio; Terricabras, Emma; Segarra, Victor
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 8 p. 2370 - 2378
反应条件
copper T=210°C; 1 h;
参考文献
Carini, David J.; Duncia, John V.; Aldrich, Paul E.; Chiu, Andrew T.; Johnson, Alexander L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2525 - 2547
反应条件
1: K3PO4; 2-(dicyclohexylphosphino)biphenyl based D-gluconamide / Pd(OAc)2 / H2O / 16 h / 80 °C 2: BF3*OEt2 / Heating View Scheme
参考文献
Tetrahedron, , vol. 58, # 29 p. 5779 - 5787
反应条件
1: PdCl2; aq. NaOH 2: benzene; methanol; hexane View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 44, # 5 p. 703 - 714
反应条件
1: 92 percent / trifluoroacetic anhydride / benzene / 23 h / Ambient temperature 2: 91 percent / diethyl ether; various solvent(s) / room temp., 17 h; reflux, 1 h 3: toluene; various solvent(s) / 2.5 h / Heating View Scheme
参考文献
Synthesis, , # 1 p. 41 - 43
反应条件
1: tetrahydrofuran / 2 h / 20 °C 2: 88 percent / 4.5 N aq. HCl / 12 h / Heating 3: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: thionyl chloride / 1 h / 25 °C 2: tetrahydrofuran / 2 h / 20 °C 3: 88 percent / 4.5 N aq. HCl / 12 h / Heating 4: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: CH2Cl2 / 2 h / 20 °C 2: thionyl chloride / 1 h / 25 °C 3: tetrahydrofuran / 2 h / 20 °C 4: 88 percent / 4.5 N aq. HCl / 12 h / Heating 5: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
参考文献
Journal of the American Chemical Society, , vol. 129, # 16 p. 5288 - 5295
反应条件
[Ni0(1,5-cyclooctadiene)2]; cesium fluoride; tri-cyclo-hexyl-phosphine in toluene T=20 - 100°C; Suzuki-Miyaura coupling; 12 h; Inert atmosphere;
参考文献
Tobisu, Mamoru; Xu, Tian; Shimasaki, Toshiaki; Chatani, Naoto
Journal of the American Chemical Society, 2011 , vol. 133, # 48 p. 19505 - 19511
