4'-甲基联苯-2-羧酸甲酯合成路线 （共 42 条）
反应条件
1: 1,3-dibromo-5,5-dimethyl-hydantoin; 2,2'-azo-bisisobutyronitrile / chloroform / 60 - 65 °C 2: potassium hydroxide / acetone / 25 - 35 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 11, # 1 p. 81 - 85
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane Reflux;
参考文献
Archiv der Pharmazie, , vol. 344, # 9 p. 617 - 626
反应条件
N-bromosuccinmide in tetrachloromethane
参考文献
US5554757 A1, ;
US 5554757 A
反应条件
dibenzoyl peroxide in tetrachloromethane
反应条件
1,3-dibromo-5,5-dimethyl-hydantoin; 2,2'-azo-bisisobutyronitrile in chloroform T=60 - 65°C;
参考文献
Organic Process Research and Development, , vol. 11, # 1 p. 81 - 85
反应条件
in tetrachloromethane
反应条件
1: 99 percent / NaOH / H2O; methanol / Heating 2: 94 percent / sulfuric acid / diethyl ether / 25 °C 3: NBS, AIBN / CCl4 / Heating View Scheme
参考文献
Huang, Horng-Chih; Reitz, David B.; Chamberlain, Timothy S.; Olins, Gillian M.; Corpus. Valerie M.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2172 - 2181
反应条件
1: 99 percent / NaOH / H2O; methanol / Heating 2: 94 percent / sulfuric acid / diethyl ether / 25 °C View Scheme
参考文献
Huang, Horng-Chih; Reitz, David B.; Chamberlain, Timothy S.; Olins, Gillian M.; Corpus. Valerie M.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2172 - 2181
反应条件
1.1: 1,3-dibromo-5,5-dimethyl-hydantoin; 2,2'-azo-bisisobutyronitrile / chloroform / 60 - 65 °C 2.1: potassium hydroxide / acetone / 25 - 35 °C 3.1: hydrogenchloride / methanol / pH 1 - 2 4.1: potassium hydroxide / acetonitrile / 2 h / 80 - 85 °C 4.2: 2 h / 60 - 65 °C / pH 5 - 5.5 View Scheme
参考文献
Reddy, Kikkuru Srirami; Srinivasan, Neti; Reddy, Chinta Raveendra; Kolla, Naveenkumar; Anjaneyulu, Yerremilli; Venkatraman, Sundaram; Bhattacharya, Apurba; Mathad, Vijayavitthal T.
Organic Process Research and Development, 2007 , vol. 11, # 1 p. 81 - 85
反应条件
1: 42.55 g / diisobutylaluminum hydride / toluene / 0.25 h / -78 - -70 °C 2: pyridinium chlorochromate / CH2Cl2 / 0.5 h / 25 °C View Scheme
参考文献
E. I. Du Pont de Nemours and Company
Patent: US5138069 A1, 1992 ;
US 5138069 A
