4’-甲基-[1,1’-联苯]-2-甲酸叔丁酯合成路线 （共 22 条）
反应条件
1: tetrahydrofuran / 2 h / 20 °C 2: 88 percent / 4.5 N aq. HCl / 12 h / Heating 3: oxalyl chloride / CH2Cl2 / 3 h / 25 °C 4: tetrahydrofuran / 1 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: oxalyl chloride / CH2Cl2 / 3 h / 25 °C 2: tetrahydrofuran / 1 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: thionyl chloride / 1 h / 25 °C 2: tetrahydrofuran / 2 h / 20 °C 3: 88 percent / 4.5 N aq. HCl / 12 h / Heating 4: oxalyl chloride / CH2Cl2 / 3 h / 25 °C 5: tetrahydrofuran / 1 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: 88 percent / 4.5 N aq. HCl / 12 h / Heating 2: oxalyl chloride / CH2Cl2 / 3 h / 25 °C 3: tetrahydrofuran / 1 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: 95 percent / thionyl chloride / 18 h / 20 °C 2: CH2Cl2 / 2 h / 20 °C 3: thionyl chloride / 1 h / 25 °C 4: tetrahydrofuran / 2 h / 20 °C 5: 88 percent / 4.5 N aq. HCl / 12 h / Heating 6: oxalyl chloride / CH2Cl2 / 3 h / 25 °C 7: tetrahydrofuran / 1 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: CH2Cl2 / 2 h / 20 °C 2: thionyl chloride / 1 h / 25 °C 3: tetrahydrofuran / 2 h / 20 °C 4: 88 percent / 4.5 N aq. HCl / 12 h / Heating 5: oxalyl chloride / CH2Cl2 / 3 h / 25 °C 6: tetrahydrofuran / 1 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1.1: 2,2,6,6-tetramethylpiperidinyl-lithium; n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 - -10 °C / |Inert atmosphere 1.2: 5 h / -78 - 20 °C / |Inert atmosphere 2.1: toluene / 20 °C 3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / toluene; ethanol / 4 h / 100 °C / |Inert atmosphere 4.1: water; hydrogenchloride / 12 h / |Reflux 5.1: oxalyl dichloride / dichloromethane / 3 h / 0 - 20 °C 5.2: 1 h / 10 - 20 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 55, p. 358 - 374,17
European Journal of Medicinal Chemistry, , vol. 55, p. 358 - 374
反应条件
1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / toluene; ethanol / 4 h / 100 °C / |Inert atmosphere 2.1: water; hydrogenchloride / 12 h / |Reflux 3.1: oxalyl dichloride / dichloromethane / 3 h / 0 - 20 °C 3.2: 1 h / 10 - 20 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 55, p. 358 - 374,17
European Journal of Medicinal Chemistry, , vol. 55, p. 358 - 374
反应条件
1.1: water; hydrogenchloride / 12 h / |Reflux 2.1: oxalyl dichloride / dichloromethane / 3 h / 0 - 20 °C 2.2: 1 h / 10 - 20 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 55, p. 358 - 374,17
European Journal of Medicinal Chemistry, , vol. 55, p. 358 - 374
反应条件
1.1: 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / tetrachloromethane / 2 h / 100 °C 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere 2.2: 1 h / 0 - 20 °C 3.1: sodium hydroxide / ethanol / 2 h / 100 °C 3.2: 20 °C / pH ~ 4 4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h 4.2: 0.5 h / 20 °C 5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C View Scheme
参考文献
SCRIPPS RESEARCH INSTITUTE, THE
Patent: US2012/309757 A1, 2012 ;
