4'-溴甲基-2-甲酸甲酯联苯合成路线 （共 24 条）
反应条件
in acetonitrile T=25 - 35°C;
参考文献
Synthetic Communications, , vol. 40, # 4 p. 530 - 534
反应条件
1: With potassium hydroxide in dimethyl sulfoxide T=25 - 50°C; 4 h; 2: With water; acetic acid in water; dimethyl sulfoxide T=20°C; pH=3.8 - 4; Product distribution / selectivity;
参考文献
CIPLA LIMITED; TURNER, Craig, Robert
Patent: WO2005/108375 A1, 2005 ;
Location in patent: Page/Page column 2-4,7,9-10 ;
反应条件
1.1: potassium hydroxide / acetone / 25 - 35 °C 2.1: hydrogenchloride / methanol / pH 1 - 2 3.1: potassium hydroxide / acetonitrile / 2 h / 80 - 85 °C 3.2: 2 h / 60 - 65 °C / pH 5 - 5.5 View Scheme
参考文献
Reddy, Kikkuru Srirami; Srinivasan, Neti; Reddy, Chinta Raveendra; Kolla, Naveenkumar; Anjaneyulu, Yerremilli; Venkatraman, Sundaram; Bhattacharya, Apurba; Mathad, Vijayavitthal T.
Organic Process Research and Development, 2007 , vol. 11, # 1 p. 81 - 85
反应条件
1: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h 2: 56 percent / manganese dioxide / CH2Cl2 / 40 h / 25 °C 3: 40 percent / N-bromosuccinimide / CCl4 / 0.5 h / Irradiation 4: 58 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) / tetrahydrofuran / 18 h / 25 °C 5: 88 percent / sodium borohydride / methanol / 0.5 h / 0 °C 6: 10percent aq. NaOH / ethanol / 14 h / Heating View Scheme
参考文献
Carini, David J.; Duncia, John V.; Aldrich, Paul E.; Chiu, Andrew T.; Johnson, Alexander L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2525 - 2547
