1: 88 percent / 4.5 N aq. HCl / 12 h / Heating 2: oxalyl chloride / CH2Cl2 / 3 h / 25 °C 3: tetrahydrofuran / 1 h / 25 °C 4: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme

1: 95 percent / thionyl chloride / 18 h / 20 °C 2: CH2Cl2 / 2 h / 20 °C 3: thionyl chloride / 1 h / 25 °C 4: tetrahydrofuran / 2 h / 20 °C 5: 88 percent / 4.5 N aq. HCl / 12 h / Heating 6: oxalyl chloride / CH2Cl2 / 3 h / 25 °C 7: tetrahydrofuran / 1 h / 25 °C 8: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme

1: CH2Cl2 / 2 h / 20 °C 2: thionyl chloride / 1 h / 25 °C 3: tetrahydrofuran / 2 h / 20 °C 4: 88 percent / 4.5 N aq. HCl / 12 h / Heating 5: oxalyl chloride / CH2Cl2 / 3 h / 25 °C 6: tetrahydrofuran / 1 h / 25 °C 7: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme

1.1: 2,2,6,6-tetramethylpiperidinyl-lithium; n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 - -10 °C / |Inert atmosphere 1.2: 5 h / -78 - 20 °C / |Inert atmosphere 2.1: toluene / 20 °C 3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / toluene; ethanol / 4 h / 100 °C / |Inert atmosphere 4.1: water; hydrogenchloride / 12 h / |Reflux 5.1: oxalyl dichloride / dichloromethane / 3 h / 0 - 20 °C 5.2: 1 h / 10 - 20 °C 6.1: dibenzoyl peroxide; N-bromosuccinmide / tetrachloromethane / 8 h / |Reflux View Scheme

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / toluene; ethanol / 4 h / 100 °C / |Inert atmosphere 2.1: water; hydrogenchloride / 12 h / |Reflux 3.1: oxalyl dichloride / dichloromethane / 3 h / 0 - 20 °C 3.2: 1 h / 10 - 20 °C 4.1: dibenzoyl peroxide; N-bromosuccinmide / tetrachloromethane / 8 h / |Reflux View Scheme

1.1: water; hydrogenchloride / 12 h / |Reflux 2.1: oxalyl dichloride / dichloromethane / 3 h / 0 - 20 °C 2.2: 1 h / 10 - 20 °C 3.1: dibenzoyl peroxide; N-bromosuccinmide / tetrachloromethane / 8 h / |Reflux View Scheme

N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane 5 h; RefluxInert atmosphere;

1: sodium hydride / N,N-dimethyl-formamide 2: water; sodium hydroxide / ethanol 3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane 4: trifluoroacetic acid / dichloromethane View Scheme

potassium tert-butylate in N,N-dimethyl acetamide T=75 - 80°C; 3 h; Inert atmosphere;