2-氰基-4'-甲基联苯合成路线 （共 139 条）
反应条件
1,1,3,3-tetramethyldisiloxane; vanadium triisopropoxide oxide in toluene T=60°C; 20 h;
参考文献
Laval, Stephane; Dayoub, Wissam; Pehlivan, Leyla; Metay, Estelle; Delbrayelle, Dominique; Mignani, Gerard; Lemaire, Marc
Tetrahedron Letters, 2014 , vol. 55, # 1 p. 23 - 26
反应条件
N-bromosuccinmide; Azo-bis(2,4-dimethyl-valeronitril) in dichloromethane T=45 - 50°C; 2 - 5 h; Industry scale;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1420016 A1, 2004 ;
Location in patent: Page 16; 17-18 ;
反应条件
bis(1,5-cyclooctadiene)nickel (0); hydrogen; trimethylaluminum; tri-cyclo-hexyl-phosphine in toluene T=130°C; P=750.075 Torr; 24 h; Schlenk technique;
参考文献
Chemical Communications, , vol. 49, # 75 p. 8362 - 8364
反应条件
bis(acetylacetonate)nickel(II); 1,1,3,3-tetramethyldisiloxane; trimethylaluminum; tri-cyclo-hexyl-phosphine in toluene T=130°C; 24 h; Inert atmosphere;
参考文献
Patra, Tuhin; Agasti, Soumitra; Akanksha; Maiti, Debabrata
Chemical Communications, 2013 , vol. 49, # 1 p. 69 - 71
反应条件
1: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating
2: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h
View Scheme
参考文献
Madasu, Suri Babu; Vekariya; Koteswaramma, Ch; Islam, Aminul; Sanasi, Paul Douglas; Korupolu, Raghu Babu
Organic Process Research and Development, 2012 , vol. 16, # 12 p. 2025 - 2030
反应条件
1: palladium diacetate; sodium peroxodisulphate
2: bis(1,5-cyclooctadiene)nickel (0); tri-cyclo-hexyl-phosphine; hydrogen; trimethylaluminum / toluene / 24 h / 130 °C / 750.08 Torr / |Schlenk technique
View Scheme
参考文献
Patra, Tuhin; Agasti, Soumitra; Modak, Atanu; Maiti, Debabrata
Chemical Communications, 2013 , vol. 49, # 75 p. 8362 - 8364
反应条件
dichloro bis(acetonitrile) palladium(II); water; silver trifluoroacetate in N,N-dimethyl acetamide; trifluoroacetic acid
T=140°C; Heck Reaction; 72 h; GloveboxInert atmosphere;
参考文献
Wan, Jung-Chih; Huang, Jun-Min; Jhan, Yu-Huei; Hsieh, Jen-Chieh
Organic Letters, 2013 , vol. 15, # 11 p. 2742 - 2745
反应条件
bis(1,5-cyclooctadiene)nickel (0); hydrogen; trimethylaluminum; tri-cyclo-hexyl-phosphine in toluene
T=130°C; P=750.075 Torr; 24 h; Schlenk technique;
参考文献
Patra, Tuhin; Agasti, Soumitra; Modak, Atanu; Maiti, Debabrata
Chemical Communications, 2013 , vol. 49, # 75 p. 8362 - 8364
反应条件
palladium in hydrogen
参考文献
Clariant GmbH
Patent: US2001/20104 A1, 2001 ;
