2-氰基-4'-甲基联苯合成路线 （共 139 条）
反应条件
Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 9 p. 2919 - 2922
反应条件
thionyl chloride in water; toluene
参考文献
US5962500 A1, ;
US 5962500 A
反应条件
manganese; cobalt (II) bromide; triphenylphosphine; trifluoroacetic acid in pyridine; N,N-dimethyl-formamide T=50°C;
参考文献
Angewandte Chemie - International Edition, , vol. 47, # 11 p. 2089 - 2092
反应条件
NiCl2[(4-MeOPh)3P]2; K3PO4*3H2O; tris(4-methoxyphenyl)-phosphine in toluene T=110°C; 5 h; Inert atmosphere; Reagent/catalyst;
参考文献
Chen, Xiaofeng; Ke, Haihua; Zou, Gang
ACS Catalysis, 2014 , vol. 4, # 2 p. 379 - 385
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene Stille Cross Coupling; 24 h; Inert atmosphereReflux;
参考文献
UNIVERSITEIT ANTWERPEN; KUVSHINOV, Alexandr; FRANCK, Philippe; DEPRAETERE, Stefaan; MAES, Bert; DE HOUWER, Johan; WYBON, Clarence; STERCKX, Hans; SERGUEEV, Serguei
Patent: WO2013/167585 A2, 2013 ;
Location in patent: Page/Page column 68 ;
反应条件
potassium fluoride; palladium diacetate; tris-(o-tolyl)phosphine in N,N-dimethyl-formamide T=120°C;
参考文献
Hatanaka, Yasuo; Goda, Ken-ichi; Okahara, Yoshinori; Hiyama, Tamejiro
Tetrahedron, 1994 , vol. 50, # 28 p. 8301 - 8316
参考文献
Sumika Fine Chemicals Co., Ltd.
Patent: US5998652 A1, 1999 ;
反应条件
sodium carbonate; palladium diacetate in anhydrous xylene; para-xylene; water; dimethyl sulfoxide
反应条件
potassium fluoride; 1,10-phenanthroline; potassium carbonate; copper(II) oxide; palladium (II) bromide in quinoline T=250°C; 0.0833333 h; Inert atmosphereMolecular sieveMicrowave irradiation;
参考文献
Goossen, Lukas J.; Linder, Bettina Zimmermanns Christophe; Rodriguez, Nuria; Lange, Paul P.; Hartung, Jens
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 16 p. 2667 - 2674
