2-氰基-4'-甲基联苯合成路线 （共 139 条）
反应条件
2,2'-bis(di-p-tolyl-phosphino)-1,1'-binaphthyl; copper(I) oxide; 1,10-phenanthroline; palladium (II) 2,4-pentanedionate in 1-methyl-pyrrolidin-2-one T=50 - 190°C; P=3375.34 Torr; Inert atmosphereMicrowave irradiation;
参考文献
Goossen, Lukas J.; Linder, Christophe; Rodriguez, Nuria; Lange, Paul P.
Chemistry - A European Journal, 2009 , vol. 15, # 37 p. 9336 - 9349
反应条件
methyl-ethyl phosphite; Ni(acac); methyl-magnesium chloride; zinc(II) chloride in tetrahydrofuran; water T=55°C;
参考文献
Miller, Joseph A.; Farrell, Robert P.
Tetrahedron Letters, 1998 , vol. 39, # 40 p. 7275 - 7278
反应条件
tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine; palladium diacetate in xylene T=130°C; 63 h;
参考文献
Tetrahedron, , vol. 57, # 37 p. 7845 - 7855
反应条件
P2O5 in tetrahydrofuran; water
反应条件
thionyl chloride in water; toluene
参考文献
US2002/115702 A1, ;
US 20020115702 A1
反应条件
palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in toluene T=120°C; 24 h; Sealed tubeInert atmosphere;
参考文献
Zhou, Chao; Liu, Qingjiang; Li, Yaming; Zhang, Rong; Fu, Xinmei; Duan, Chunying
Journal of Organic Chemistry, 2012 , vol. 77, # 22 p. 10468 - 10472
反应条件
N-hexadecyl-N,N,N-trimethylammonium bromide; palladium; triethylamine in water T=110°C; Suzuki-Miyaura Coupling; 0.5 h; Microwave irradiation; Reagent/catalyst;
参考文献
Civicos, Jose F.; Alonso, Diego A.; Najera, Carmen
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 14-15 p. 2771 - 2776
反应条件
palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in toluene T=120°C; 40 h; Inert atmosphereSealed tube;
参考文献
Zhou, Chao; Li, Yaming; Lu, Yang; Zhang, Rong; Jin, Kun; Fu, Xinmei; Duan, Chunying
Chinese Journal of Chemistry, 2013 , vol. 31, # 10 p. 1269 - 1273
反应条件
hydrogenchloride in tetrahydrofuran
反应条件
toluene-4-sulfonic acid; orthoformic acid triethyl ester; copper(l) chloride; sodium nitrite T=50°C; Gomberg-Bachmann-Hey reaction; 0.75 h;
参考文献
Tetrahedron Letters, , vol. 52, # 38 p. 4950 - 4953
