2-氰基-4'-甲基联苯合成路线 （共 139 条）
反应条件
copper(I) oxide in N,N-dimethyl-formamide T=130°C; 12 h;
参考文献
Wen, Qiaodong; Jin, Jisong; Mei, Yuncai; Lu, Ping; Wang, Yanguang
European Journal of Organic Chemistry, 2013 , # 19 p. 4032 - 4036
反应条件
bis-triphenylphosphine-palladium(II) chloride; potassium phosphate in toluene 1 h; Heating;
参考文献
Urawa, Yoshio; Naka, Hiroyuki; Miyazawa, Mamoru; Souda, Shigeru; Ogura, Katsuyuki
Journal of Organometallic Chemistry, 2002 , vol. 653, # 1-2 p. 269 - 278
反应条件
C46H55ClFeN3Pd; lithium chloride in tetrahydrofuran T=20°C; Kumada coupling reaction; 12 h; Inert atmosphere;
参考文献
Ren, Gerui; Cui, Xiuling; Wu, Yangjie
European Journal of Organic Chemistry, 2010 , # 12 p. 2372 - 2378
反应条件
1: para-bromotoluene With magnesium; lithium chloride in tetrahydrofuran T=20°C; Inert atmosphere; 2: ortho-fluorobromobenzene With magnesium in tetrahydrofuran T=20 - 60°C; Inert atmosphere; 3: N-cyano-N-phenyl-p-methylbenzenesulfonamide in tetrahydrofuran T=20°C; Inert atmosphere;
参考文献
Anbarasan, Pazhamalai; Neumann, Helfried; Beller, Matthias
Chemistry - A European Journal, 2011 , vol. 17, # 15 p. 4217 - 4222
反应条件
1: 72 percent / acetic anhydride; pyridine 2: 71 percent / copper(II) oxide; potassium carbonate; potassium fluoride / palladium(II) bromide; 1,10-phenanthroline / quinoline / 24 h / 170 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 72, # 19 p. 7473 - 7476
反应条件
bis-triphenylphosphine-palladium(II) chloride; lithium chloride in N,N-dimethyl-formamide Inert atmosphere;
参考文献
Sanchez, Ana I.; Martinez-Barrasa, Valentin; Burgos, Carolina; Vaquero, Juan J.; Alvarez-Builla, Julio; Terricabras, Emma; Segarra, Victor
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 8 p. 2370 - 2378
反应条件
in N-methyl-acetamide; water
参考文献
Merck and Co., Inc.
Patent: US5583130 A1, 1996 ;
反应条件
bis-triphenylphosphine-palladium(II) chloride; lithium perchlorate in tetrahydrofuran T=67 - 69°C; 4.5 - 6.5 h; Product distribution / selectivity;
参考文献
WO2008/87656 A2, ;
Page/Page column 9-11 ;
反应条件
in tetrahydrofuran T=0°C; 2.25 h; Inert atmosphere;
参考文献
Anbarasan, Pazhamalai; Neumann, Helfried; Beller, Matthias
Chemistry - A European Journal, 2010 , vol. 16, # 16 p. 4725 - 4728
