2-氰基-4'-甲基联苯合成路线 （共 139 条）
反应条件
4C3H6N6*Pd(2+)*2C2H3O2(1-); sodium carbonate T=110°C; Suzuki-Miyaura Coupling; 2 h; Green chemistry;
参考文献
Edwards, Grant A.; Trafford, Mitchell A.; Hamilton, Alaina E.; Buxton, Audrey M.; Bardeaux, Matthew C.; Chalker, Justin M.
Journal of Organic Chemistry, 2014 , vol. 79, # 5 p. 2094 - 2104
反应条件
in benzene Ambient temperature;
参考文献
Sain, Bir; Sandhu, Jagir S.
Journal of Organic Chemistry, 1990 , vol. 55, # 8 p. 2545 - 2546
反应条件
bis(acetylacetonate)nickel(II); methyl-ethyl phosphite in tetrahydrofuran T=40°C; 6 h;
参考文献
Miller, Joseph A.; Farrell, Robert P.
Tetrahedron Letters, 1998 , vol. 39, # 36 p. 6441 - 6444
反应条件
NiCl2((PPh3)P)2; triphenylphosphine in tetrahydrofuran T=55°C; 5 h;
参考文献
Miller, Joseph A.; Farrell, Robert P.
Tetrahedron Letters, 1998 , vol. 39, # 36 p. 6441 - 6444
反应条件
1: toluene / 2 h / 110 °C 2: Pd(PPh3)2Cl2; K3PO4 / toluene / 12 h / 100 °C / |Schlenk technique; |Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 15, # 11 p. 2742 - 2745
反应条件
1: tetrahydrofuran / 2 h / 20 °C 2: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: thionyl chloride / 1 h / 25 °C 2: tetrahydrofuran / 2 h / 20 °C 3: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: 95 percent / thionyl chloride / 18 h / 20 °C 2: CH2Cl2 / 2 h / 20 °C 3: thionyl chloride / 1 h / 25 °C 4: tetrahydrofuran / 2 h / 20 °C 5: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
反应条件
1: CH2Cl2 / 2 h / 20 °C 2: thionyl chloride / 1 h / 25 °C 3: tetrahydrofuran / 2 h / 20 °C 4: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2525 - 2547
参考文献
Goossen, Lukas J.; Zimmermann, Bettina; Knauber, Thomas
Angewandte Chemie - International Edition, 2008 , vol. 47, # 37 p. 7103 - 7106
