2-氰基-4'-甲基联苯合成路线 （共 139 条）
反应条件
MMPP in methanol T=20°C; 0.00333333 h;
参考文献
Journal of Organic Chemistry, , vol. 77, # 21 p. 9915 - 9920
反应条件
sodium carbonate in water; ethyl acetate; isopropyl alcohol T=50°C; Suzuki-Miyaura coupling; 0.00111111 h; Microchannel flow reactor;
参考文献
Yamada, Yoichi M. A.; Watanabe, Toshihiro; Beppu, Tomohiko; Fukuyama, Naoshi; Torii, Kaoru; Uozumi, Yasuhiro
Chemistry - A European Journal, 2010 , vol. 16, # 37 p. 11311 - 11319
反应条件
1: 4-methyl-chlorobenzene With iodine; magnesium in tetrahydrofuran; toluene Grignard reaction; Inert atmosphereReflux; 2: ortho-chloro-benzonitrile With manganese (II) chloride in tetrahydrofuran; toluene T=-5°C; Grignard reaction; 4 h;
参考文献
Asian Journal of Chemistry, , vol. 22, # 8 p. 6341 - 6344
反应条件
1.1: 2,2,6,6-tetramethylpiperidinyl-lithium; n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 - -10 °C / |Inert atmosphere 1.2: 5 h / -78 - 20 °C / |Inert atmosphere 2.1: toluene / 20 °C 3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / toluene; ethanol / 4 h / 100 °C / |Inert atmosphere View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 55, p. 358 - 374,17
European Journal of Medicinal Chemistry, , vol. 55, p. 358 - 374
反应条件
acetophenone oxime carbapalladacycle anchored to SiO2; potassium carbonate in water Suzuki reaction; 48 h; Heating; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 69, # 2 p. 439 - 446
反应条件
1: 98 percent / pyridine / 1.) 0 deg C, 5 min, 2.) r.t., 25 h 2: 1.) Mg, I2; n-Bu3SnCl, 2.) Pd(PPh3)2Cl2, LiCl / 1.) THF, reflux, 30 min; THF, reflux, 20 h, 2.) DMF, 98 deg C, 24 h View Scheme
参考文献
Farmaco, , vol. 52, # 3 p. 147 - 155
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=25°C; Negishi cross-coupling; 10 h; Inert atmosphere;
参考文献
Chemistry - A European Journal, , vol. 16, # 1 p. 248 - 253
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=25°C; Negishi cross-coupling; 10 h; Inert atmosphere;
参考文献
Chemistry - A European Journal, , vol. 16, # 1 p. 248 - 253
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=25°C; Negishi cross-coupling; 24 h; Inert atmosphere;
参考文献
Chemistry - A European Journal, , vol. 16, # 1 p. 248 - 253
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=25°C; Negishi cross-coupling; 48 h; Inert atmosphere;
参考文献
Chemistry - A European Journal, , vol. 16, # 1 p. 248 - 253
