2-氰基-4'-溴甲基联苯合成路线 （共 55 条）
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; water; acetic acid in chlorobenzene T=90°C; 11 h;
参考文献
JP2005/82496 A, ;
Page/Page column 13 ;
反应条件
sodium hydrogencarbonate in dimethyl sulfoxide
反应条件
potassium carbonate in methanol T=50 - 55°C; 24 h;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2006/15134 A1, 2006 ;
Location in patent: Page/Page column 16; 21-22 ;
反应条件
1: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h View Scheme
参考文献
Carini, David J.; Duncia, John V.; Aldrich, Paul E.; Chiu, Andrew T.; Johnson, Alexander L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2525 - 2547
反应条件
1: 2-n-propyl-4-methyl-6-(1'-methylbenzimidazol-2'-yl)benzimidazole With potassium tert-butylate in isobutyramide T=20°C; 1 h; 2: 2-[4-(bromomethyl)phenyl]benzonitrile in isobutyramide T=5 - 10°C; 2 h;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2004/236113 A1, 2004 ;
Location in patent: Page 4 ;
反应条件
1.1: potassium carbonate / ethyl acetate; water / 25 h / 40 - 50 °C 2.1: 2,6-dimethylpyridine / toluene / 2 h / 5 - 30 °C 3.1: sodium azide / toluene / 50 h / Reflux 4.1: sodium hydroxide; water / toluene / 12 h / 20 - 30 °C 4.2: pH 1 - 2.5 View Scheme
参考文献
Chinta, Raveendra Reddy; Nangi, Gangadhara Bhima Shankar; Nayini, Mahendar Reddy; Yallapa, Somappa Somannavar; Budidet, Shankar Reddy; Aminul, Islam; Meenakshisunderam, Sivakumaran
Patent: US2013/144067 A1, 2013 ;
反应条件
hydrogen; platinum on carbon in n-heptane; water T=60 - 70°C; P=7.35576 - 29.423 Torr;
参考文献
Sumitomo Chemical Company, Limited
Patent: EP1683777 A1, 2006 ;
Location in patent: Page/Page column 5 ;
反应条件
1: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h 3: 89 percent / 10percent HCl / tetrahydrofuran / 4 h / 25 °C View Scheme
参考文献
Carini, David J.; Duncia, John V.; Aldrich, Paul E.; Chiu, Andrew T.; Johnson, Alexander L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2525 - 2547
反应条件
sodium carbonate in acetone T=58°C; 4 h;
参考文献
SMS PHARMACEUTICALS LIMITED; POTLURI, Ramesh, Babu; DEHURY, Sanjay, Kumar; VENKATA SUBHRAMANIAN, Harihara Krishnan
Patent: WO2010/133909 A2, 2010 ;
Location in patent: Page/Page column 14-15 ;
反应条件
in ice-water; N,N-dimethyl-formamide
参考文献
Ciba-Geigy Corp
Patent: US5399578 A1, 1995 ;
US 5399578 A
