2-氯-4-氟-5-硝基苯甲酸合成路线 （共 5 条）
反应条件
sulfuric acid; nitric acid T=20°C; 1 h;
参考文献
Sbardella, Gianluca; Mai, Antonello; Artico, Marino; Setzu, Maria Giovanna; Poni, Graziella; La Colla, Paolo
Farmaco, 2004 , vol. 59, # 6 p. 463 - 471
反应条件
sulfuric acid; water T=70 - 110°C; 3 - 6.45 h; Product distribution / selectivity;
参考文献
MITENI S.p.A.
Patent: EP1853548 B1, 2009 ;
Location in patent: Page/Page column 6 ;
反应条件
1: 92 percent / Co(OAc)2*4H2O, Mn(OAc)2*4H2O, tert-butyl peroxide, 48percent HBr, O2 / acetic acid / 3 h / 130 - 160 °C / 15514.4 Torr 2: 83 percent / fuming HNO3, conc. H2SO4 / 0 deg C, 1 h then 50 deg C, 1.5 h View Scheme
参考文献
Synthesis, , # 10 p. 883 - 887
反应条件
diborane in tetrahydrofuran 1.5 h; Heating;
参考文献
Wheeler, Thomas N.; Craig, Todd A.; Morland, Robert B.; Ray, John, A.
Synthesis, 1987 , # 10 p. 883 - 887
反应条件
1: 93 percent / B2H6 / tetrahydrofuran / 1.5 h / Heating 2: 68 percent / SnCl2*2H2O / ethanol / 2 h / 70 °C View Scheme
参考文献
Wheeler, Thomas N.; Craig, Todd A.; Morland, Robert B.; Ray, John, A.
Synthesis, 1987 , # 10 p. 883 - 887
