2-氨基-9-(3-羟基丙氧基)-3H-嘌呤-6-酮合成路线 （共 8 条）
反应条件
4-(N,N-dimethlyamino)pyridine in N,N-dimethyl-formamide 2 h; Ambient temperature;
参考文献
Beecham Group p.l.c.
Patent: US4965270 A1, 1990 ;
反应条件
ammonia; palladium in formic acid; water
参考文献
Beecham Group p.l.c.
Patent: US4965270 A1, 1990 ;
反应条件
hydrogen; palladium on activated charcoal in formic acid
参考文献
Harnden, M. R.; Parkin, A.; Wyatt, P. G.
Tetrahedron Letters, 1988 , vol. 29, # 6 p. 701 - 704
反应条件
hydrogenchloride in ethanol
Heating;
参考文献
Harnden, M. R.; Wyatt, P. G.
Tetrahedron Letters, 1990 , vol. 31, # 15 p. 2185 - 2188
反应条件
1: 95 percent / H2 / Pd/C
2: 89 percent / PPh3, DEAD / tetrahydrofuran
3: 60 percent / aq. HCl / ethanol / Heating
View Scheme
参考文献
Harnden, M. R.; Wyatt, P. G.
Tetrahedron Letters, 1990 , vol. 31, # 15 p. 2185 - 2188
反应条件
2: 89 percent / H2 / 10percent Pd-C / aq. formic acid
View Scheme
参考文献
Harnden, M. R.; Parkin, A.; Wyatt, P. G.
Tetrahedron Letters, 1988 , vol. 29, # 6 p. 701 - 704
反应条件
1: 63 percent / BF3*Et2O / 1,2-dimethoxy-ethane / 60 - 80 °C
3: 89 percent / H2 / 10percent Pd-C / aq. formic acid
View Scheme
参考文献
Harnden, M. R.; Parkin, A.; Wyatt, P. G.
Tetrahedron Letters, 1988 , vol. 29, # 6 p. 701 - 704
反应条件
1: 89 percent / PPh3, DEAD / tetrahydrofuran
2: 60 percent / aq. HCl / ethanol / Heating
View Scheme
参考文献
Harnden, M. R.; Wyatt, P. G.
Tetrahedron Letters, 1990 , vol. 31, # 15 p. 2185 - 2188
