4-(三甲基硅基氧基)-5,6-二氢吡啶-1(2H)-甲酸苄酯合成路线 （共 3 条）
反应条件
1: 1-benzyloxycarbonyl-piperidin-4-one With lithium hexamethyldisilazane in tetrahydrofuran T=-78°C; 0.5 h; Inert atmosphere; 2: chloro-trimethyl-silane T=-78 - 20°C; 0.166667 h;
参考文献
WO2013/177253 A2, ;
Page/Page column 74; 75 ;
反应条件
1: With triethylamine in N,N-dimethyl-formamide T=80°C; 18 h; 2: With chloro-trimethyl-silane T=80°C; 18 h;
参考文献
WO2012/66077 A1, ;
Page/Page column 22 ;
WO 2012/066077 A1
反应条件
1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in N,N-dimethyl-formamide T=0 - 20°C; 0.5 h;
参考文献
GLAXOSMITHKLINE LLC; ADAMS, Nicholas, David; CHAUDHARI, Amita, M.; KIESOW, Terence, John; McSHERRY, Allison, K.; MOORE, Michael, Lee; PARRISH, Cynthia, Ann; REIF, Alexander, Joseph; RIDGERS, Lance, Howard
Patent: WO2014/8223 A2, 2014 ;
Location in patent: Page/Page column 110 ;
