N-苄氧羰基-L-脯氨酸合成路线 （共 150 条）
反应条件
1: 1.) triethylamine, isobutyl chloroformate, 2.) ammonia / 1.) chloroform, 0 deg C, 2 h, 2.) chloroform, RT, overnight 2: 88.4 percent / hydrogen / 10percent palladium on carbon / methanol / 9 h / Ambient temperature 3: 36.8 percent / lithium aluminum hydride / tetrahydrofuran / 33 h / Heating View Scheme
参考文献
Morikawa; Honda; Endoh -i.; Matsumoto; Akamatsu -i.; Mitsui; Koizumi
Journal of Pharmaceutical Sciences, 1991 , vol. 80, # 9 p. 837 - 842
反应条件
1.1: ethyl chloroformate; triethylamine / tetrahydrofuran / 0.33 h / -5 °C 1.2: 99 percent / NH4OH / tetrahydrofuran; H2O / 18 h / 20 °C 2.1: 83 percent / trifluoroacetic anhydride; triethylamine / tetrahydrofuran / 1 h / 0 °C View Scheme
参考文献
Hartikka, Antti; Arvidsson, Per I.
European Journal of Organic Chemistry, 2005 , # 20 p. 4287 - 4295
反应条件
1: 94 percent / dicyclohexylcarbodiimide, HOBt / dimethylformamide / Ambient temperature 2: H2 / Pd/C / methanol / 6 h View Scheme
参考文献
Corma, A.; Iglesias, M.; Pino, C. del; Sanchez, F.
Journal of Organometallic Chemistry, 1992 , vol. 431, # 2 p. 233 - 246
反应条件
1: 4-methylmorpholine / CH2Cl2 / 0.25 h / -15 °C 2: 4-methylmorpholine / CH2Cl2 / a) -15 deg C, 1 h, b) RT, 12 h 3: 10percent Pd/C, cyclohexene / methanol / 5 h / Heating 4: methanol / 110 h / 62 - 65 °C 5: 70 percent / LiAlH4 / tetrahydrofuran / 72 h / 65 - 68 °C View Scheme
参考文献
Falorni, Massimo; Satta, Michele; Conti, Sandra; Giacomelli, Giampaolo
Tetrahedron: Asymmetry, 1993 , vol. 4, # 11 p. 2389 - 2398
反应条件
1: 4-methylmorpholine / CH2Cl2 / 0.25 h / -15 °C 2: 4-methylmorpholine / CH2Cl2 / a) -15 deg C, 1 h, b) RT, 12 h 3: 10percent Pd/C, cyclohexene / methanol / 5 h / Heating 4: methanol / 110 h / 62 - 65 °C 5: 62 percent / LiAlH4 / tetrahydrofuran / 72 h / 65 - 68 °C View Scheme
参考文献
Falorni, Massimo; Satta, Michele; Conti, Sandra; Giacomelli, Giampaolo
Tetrahedron: Asymmetry, 1993 , vol. 4, # 11 p. 2389 - 2398
反应条件
1: 35.9 g / boron trifluoride etherate / 1 h / Heating 2: 52.7 percent / tetrahydrofuran / 16 h / Ambient temperature View Scheme
参考文献
Corey, E.J.; Shibata, Saizo; Bakshi, Raman K.
Journal of Organic Chemistry, 1988 , vol. 53, # 12 p. 2861 - 2863
反应条件
1: BH3 / tetrahydrofuran / 0 deg C to room temperature 2: pyridine / 0 deg C to room temperature 3: NaN3 / dimethylformamide / Heating 4: PPh3, aq. NH3 / methanol View Scheme
参考文献
Vega-Penaloza, Alberto; Sanchez-Antonio, Omar; Escudero-Casao, Margarita; Tasnadi, Gabor; Fueloep, Ferenc; Juaristi, Eusebio
Synthesis (Germany), 2013 , vol. 45, # 17 art. no. SS-2013-M0321-OP, p. 2458 - 2468
反应条件
1.1: N-methyl morpholine; isobutyl chloroformate / tetrahydrofuran / 0.17 h / -25 °C 1.2: 100 percent / N-methyl morpholine / tetrahydrofuran / 2 h / -25 °C 2.1: 79 percent / aq. NaOH / methanol; tetrahydrofuran / 3 h / 20 °C 3.1: 83 percent / hydrogen / palladium on carbon / methanol / 1.5 h View Scheme
参考文献
Erkkilae, Anniina; Pihko, Petri M.
Journal of Organic Chemistry, 2006 , vol. 71, # 6 p. 2538 - 2541
反应条件
n-ethyl morpholine; benzotriazol-1-ol in dichloromethane 1) 0 deg C, 2 h, 2) overnight, r.t.;
参考文献
Appel, Rolf; Glaesel, Ursula
Chemische Berichte, 1980 , vol. 113, # 11 p. 3511 - 3516
反应条件
pyridine in acetonitrile T=20°C; 1.5 h; further solvent, base;
参考文献
Il'ina, A. V.; Davidovich, Yu. A.; Rogozhin, S. V.; Moiseenkov, A. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1984 , vol. 33, p. 1067 - 1070
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1984 , # 5 p. 1163 - 1165
